By a News Reporter-Staff News Editor at Drug Week -- Current study results on Enzymes and Coenzymes have been published. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "A series of novel amphiphilic chitosan derivatives, cholic acid modified N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride (HTCC-CA) with different quaternization degrees and cholic acid substitutions were synthesized in this study. HTCC-CA is biocompatible and forms particles in aqueous solution."
Our news journalists obtained a quote from the research from Fudan University, "The binding with superoxide dismutase (SOD) at pH 6.8 destroys the original aggregates of HTCC-CA and produces smaller SOD/HTCC-CA complex nanoparticles via electrostatic and hydrophobic interactions. The SOD loading efficiency and loading capacity of HTCC-CA can reach to more than 90% and 45%, respectively. Confocal laser scanning microscopy observation and flow cytometry analysis reveal that SOD/HTCC-CA complex nanoparticles greatly enhance the cellular internalization of the loaded SOD. The SOD activities and malonaldehyde concentrations in the serum and organs of the rats, administrated intravenously with free SOD, free HTCC-CA, and SOD/HTCC-CA nanoparticles, were assayed to evaluate the antioxidant efficiency in vivo."
According to the news editors, the research concluded: "The results demonstrate that free HTCC-CA is effective to scavenge superoxide radicals in the blood circulation and SOD/HTCC-CA nanoparticles have better antioxidant efficiency than free SOD as well as free HTCC-CA."
For more information on this research see: Cholic acid modified N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride for superoxide dismutase delivery. International Journal of Pharmaceutics, 2013;454(1):425-434. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting Y. Cheng, Fudan University, State Key Lab Mol Engn Polymers, Dept. of Macromol Sci, Shanghai 200433, People's Republic of China. Additional authors for this research include H.X. Cai, B.O. Yin and P. Yao (see also Enzymes and Coenzymes).
Keywords for this news article include: Asia, Anions, Shanghai, Chlorides, Electrolytes, Nanoparticle, Nanotechnology, Oxidoreductases, Hydrochloric Acid, Superoxide Dismutase, Emerging Technologies, Enzymes and Coenzymes, Reactive Oxygen Species, People's Republic of China
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