By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Peptides and Proteins. According to news reporting originating in Hsinchu, Taiwan, by NewsRx journalists, research stated, "Highly pathogenic avian influenza H5N1 viruses can result in poultry and occasionally in human mortality. A safe and effective H5N1 vaccine is urgently needed to reduce the pandemic potential."
The news reporters obtained a quote from the research from National Tsing Hua University, "Hemagglutinin (HA), a major envelope protein accounting for approximately 80% of spikes in influenza virus, is often used as a major antigen for subunit vaccine development. In this study, we conducted a systematic study of the immune response against influenza virus infection following immunization with recombinant HA proteins expressed in insect (Sf9) cells, insect cells that contain exogenous genes for elaborating N-linked glycans (Mimic) and mammalian cells (CHO). While the antibody titers are higher with the insect cell derived HA proteins, the neutralization and HA inhibition titers are much higher with the mammalian cell produced HA proteins. Recombinant HA proteins containing tri-or tetra-antennary complex, terminally sialylated and asialyated-galactose type N-glycans induced better protective immunity in mice to lethal challenge."
According to the news reporters, the research concluded: "The results are highly relevant to issues that should be considered in the production of fragment vaccines."
For more information on this research see: Different immunity elicited by recombinant H5N1 hemagglutinin proteins containing pauci-mannose, high-mannose, or complex type N-glycans. Plos One, 2013;8(6):e66719. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
Our news correspondents report that additional information may be obtained by contacting S.C. Lin, Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan. Additional authors for this research include J.T. Jan, B. Dionne, M. Butler, M.H. Huang, C.Y. Wu, C.H. Wong and S.C Wu (see also Peptides and Proteins).
Keywords for this news article include: Asia, Taiwan, Hsinchu, Amino Acids, Peptides and Proteins.
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