By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Butyric Acids are presented in a new report. According to news originating from Cochin, India, by NewsRx correspondents, research stated, "Liver is one of the major organs in vertebrates and hepatocytes are damaged by many factors. The liver cell maintenance and multiplication after injury and treatment gained immense interest."
Our news journalists obtained a quote from the research from Cochin University, "The present study investigated the role of Gamma aminobutyric acid (GABA) and serotonin or 5-hydroxytryptamine (5-HT) coupled with chitosan nanoparticles in the functional regulation of Gamma aminobutyric acid B and 5-hydroxy tryptamine 2A receptors mediated cell signaling mechanisms, extend of DNA methylation and superoxide dismutase activity during enhanced liver cell proliferation. Liver injury was achieved by partial hepatectomy of male Wistar rats and the GABA and 5-HT chitosan nanoparticles treatments were given intraperitoneally. The experimental groups were sham operated control (C), partially hepatectomiserl rats with no treatment (PHNT), partially hepatectomised rats with GABA chitosan nanoparticle (GCNP), 5-HT chitosan nanoparticle (SCNP) and a combination of GABA and 5-HT chitosan nanoparticle (GSCNP) treatments. In GABA and 5-HT chitosan nanoparticle treated group there was a significant decrease (P
According to the news editors, the research concluded: "The Gamma aminobutyric acid B and 5-hydroxy tryptamine 2A receptors coupled signaling elements played an important role in GABA and 5-HT chitosan nanoparticles induced liver cell proliferation which has therapeutic significance in liver disease management."
For more information on this research see: Gamma aminobutyric acid B and 5-hydroxy tryptamine 2A receptors functional regulation during enhanced liver cell proliferation by GABA and 5-HT chitosan nanoparticles treatment. European Journal of Pharmacology, 2013;715(1-3):154-163. European Journal of Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmacology - www.elsevier.com/wps/product/cws_home/506087)
The news correspondents report that additional information may be obtained from J. Shilpa, Cochin Univ Sci & Technol, Mol Neurobiol & Cell Biol Unit, Center Neurosci, Dept. of Biotechnol, Cochin 682022, Kerala, India. Additional authors for this research include M.A. Pretty, M. Anitha and C.S. Paulose (see also Butyric Acids).
Keywords for this news article include: Asia, India, Cochin, Treatment, Amino Acids, Tryptamines, Nanoparticle, Nanotechnology, Aminobutyric Acids, Cell Proliferation, Biogenic Monoamines, Emerging Technologies
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