By a News Reporter-Staff News Editor at Drug Week -- Current study results on Nanoparticles have been published. According to news reporting from Shaoxing, People's Republic of China, by NewsRx journalists, research stated, "To evaluate the effect of borneol on the brain targeting efficiency of aprotinin-conjugated poly (ethyleneglycol)-poly (L-lactic-co-glycolic acid) nanoparticles (Apr-NP) and the activity of huperzine A (Hup A) loaded nanoparticles to AD rats. Apr-NP was prepared by emulsion and solvent evaporation method."
The news correspondents obtained a quote from the research from Peoples Hospital, "The uptake of Apr-NP alone or combined with borneol by brain capillary endothelial cells (BCECs) was evaluated by incorporating coumarin-6 as a tracer. In vivo imaging and the distribution of Hup A in the brain were measured to investigate the brain delivery of Apr-NP in rats, with or without the oral administration of borneol. Morris water maze was used to evaluate the memory improvement effect of Hup A loaded nanoparticles (Apr-NP-Hup). Co-incubation with borneol could increase the uptake of nanoparticles by BCECs. Nanoparticles delivered into the rat brain were enhanced significantly by the co-administration of borneol. The pharmacological effects of Hup A loaded nanoparticles on improving the memory impairment of AD rats were greatly improved when combined with borneol. Borneol is a promising enhancer for brain-targeting delivery systems."
According to the news reporters, the research concluded: "When co-administered with aprotinin-modified nanoparticles, borneol could improve the brain targeting efficiency of nanoparticles significantly."
For more information on this research see: The Use of Borneol as an Enhancer for Targeting Aprotinin-Conjugated PEG-PLGA Nanoparticles to the Brain. Pharmaceutical Research, 2013;30(10):2560-2572. Pharmaceutical Research can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Pharmaceutical Research - www.springerlink.com/content/0724-8741/)
Our news journalists report that additional information may be obtained by contacting L. Zhang, Shaoxing Peoples Hosp, Dept. of Pharm, Shaoxing 312000, Zhejiang, People's Republic of China. Additional authors for this research include L.M. Han, J. Qin, W.Y. Lu and J.X. Wang (see also Nanoparticles).
Keywords for this news article include: Asia, Shaoxing, Nanotechnology, Emerging Technologies, People's Republic of China
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