By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Chemical Physics have been published. According to news reporting from Piscataway, New Jersey, by NewsRx journalists, research stated, "Single solid-state nanopores find increasing use for electrical detection and/or manipulation of macromolecules. These applications exploit the changes in signals due to the geometry and electrical properties of the molecular species found within the nanopore."
The news correspondents obtained a quote from the research from Rutgers State University, "The sensitivity and resolution of such measurements are also influenced by the geometric and electrical properties of the nanopore. This paper continues the development of an analytical theory to predict the electrochemical impedance spectra of nanopores by including the influence of the presence of an unfolded protein using the variable topology finite Warburg impedance model previously published by the authors. The local excluded volume of, and charges present on, the segment of protein sampled by the nanopore are shown to influence the shape and peak frequency of the electrochemical impedance spectrum. An analytical theory is used to relate the capacitive response of the electrical double layer at the surface of the protein to both the charge density at the protein surface and the more commonly measured zeta potential."
According to the news reporters, the research concluded: "Illustrative examples show how the theory predicts that the varying sequential regions of surface charge density and excluded volume dictated by the protein primary structure may allow for an impedance-based approach to identifying unfolded proteins."
For more information on this research see: Theoretical models for electrochemical impedance spectroscopy and local zeta-potential of unfolded proteins in nanopores. Journal of Chemical Physics, 2013;139(10):504-511. Journal of Chemical Physics can be contacted at: Amer Inst Physics, Circulation & Fulfillment Div, 2 Huntington Quadrangle, Ste 1 N O 1, Melville, NY 11747-4501, USA. (American Institute of Physics - www.aip.org/; Journal of Chemical Physics - jcp.aip.org/)
Our news journalists report that additional information may be obtained by contacting M.J. Vitarelli, Rutgers State University, Dept. of Chem & Chem Biol, Piscataway, NJ 08854, United States (see also Chemical Physics).
Keywords for this news article include: Peptides, Proteins, Chemistry, Piscataway, New Jersey, Amino Acids, United States, Electrochemical, Chemical Physics, North and Central America
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