By a News Reporter-Staff News Editor at Stem Cell Week -- New research on Stem Cell Research is the subject of a report. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "Human pluripotent stem cell-derived neural crest stem cells (NCSCs) provide a promising cell source for generating Schwann cells in the treatment of neurodegenerative diseases and traumatic injuries in the peripheral nervous system. Influencing cell behavior through a synthetic matrix topography has been shown to be an effective approach to directing stem cell proliferation and differentiation."
Our news editors obtained a quote from the research from Johns Hopkins University, "Here we have investigated the effect of nanofiber topography on the differentiation of human embryonic stem cell-derived NCSCs towards the Schwann cell lineage. Using electrospun fibers of different diameters and alignments we demonstrated that aligned fiber matrices effectively induced cell alignment, and that fiber matrices with average diameters of 600nm and 1.6?m most effectively promoted NCSC differentiation towards the Schwann cell lineage compared with random fibers and two-dimensional tissue culture plates. More importantly, human NCSCs that were predifferentiated in Schwann cell medium for 2weeks exhibited higher sensitivity to the aligned fiber topography than undifferentiated NCSCs."
According to the news editors, the research concluded: "This study provides an efficient protocol for Schwann cell derivation by combining an aligned nanofiber matrix and an optimized differentiation medium, and highlights the importance of matching extrinsic matrix signaling with cell intrinsic programming in a temporally specific manner."
For more information on this research see: Enhanced differentiation of human neural crest stem cells towards the Schwann cell lineage by aligned electrospun fiber matrix. Acta Biomaterialia, 2013;9(8):7727-36. (Elsevier - www.elsevier.com; Acta Biomaterialia - www.elsevier.com/wps/product/cws_home/702994)
The news editors report that additional information may be obtained by contacting Y.J. Ren, Dept. of Materials Science and Engineering, Johns Hopkins University, 205 Maryland Hall, Baltimore, MD 21218, United States. Additional authors for this research include S. Zhang, R. Mi, Q. Liu, X. Zeng, M. Rao, A. Hoke and H.Q Mao (see also Stem Cell Research).
Keywords for this news article include: Maryland, Baltimore, Neuroglia, United States, Schwann Cells, Peripheral Nerves, Stem Cell Research, North and Central America.
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