By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news reporting originating from Zurich, Switzerland, by NewsRx correspondents, research stated, "This study was directed to the measurement of the mechanical response of fetal membranes to physiologically relevant loading conditions. Characteristic mechanical parameters were determined and their relation to the microstructural constituents collagen and elastin as well as to the pyridinium cross-link concentrations analyzed. 51 samples from twelve fetal membranes were tested on a custom-built inflation device, which allows mechanical characterization within a multiaxial state of stress."
Our news editors obtained a quote from the research from the Swiss Federal Institute of Technology, "Methods of nonlinear continuum mechanics were used to extract representative mechanical parameters. Established biochemical assays were applied for the determination of the collagen and elastin content. Collagen cross-link concentrations were determined by high-performance liquid chromatography measurements. The results indicate a distinct correlation between the mechanical parameters of high stretch stiffness and membrane tension at rupture and the biochemical data of collagen content and pyridinoline as well as deoxypyridinoline concentrations. No correlation was observed between the mechanical parameters and the elastin content. Moreover, the low stretch stiffness is, with a value of 105 ± 31 x 10(-3) N/ mm much higher for a biaxial state of stress compared to a uniaxial stress configuration. Determination of constitutive model equations leads to better predictive capabilities for a reduced polynomial hyperelastic model with only terms related to the second invariant, I 2, of the right Cauchy-Green deformation tensor. Relevant insights were obtained on the mechanical behavior of fetal membranes. Collagen and its cross-linking were shown to determine membrane's stiffness and strength for multiaxial stress states."
According to the news editors, the research concluded: "Their nonlinear deformation behavior characterizes the fetal membranes as I 2 material."
For more information on this research see: Multiaxial mechanical behavior of human fetal membranes and its relationship to microstructure. Biomechanics and Modeling In Mechanobiology, 2013;12(4):747-62. (Springer - www.springer.com; Biomechanics and Modeling In Mechanobiology - www.springerlink.com/content/1617-7959/)
The news editors report that additional information may be obtained by contacting W. Buerzle, Dept. of Mechanical and Process Engineering, Swiss Federal Institute of Technology, Zurich, Switzerland. Additional authors for this research include C.M. Haller, M. Jabareen, J. Egger, A.S. Mallik, N. Ochsenbein-Koelble, M. Ehrbar and E. Mazza (see also Proteins).
Keywords for this news article include: Zurich, Europe, Collagen, Chemistry, Switzerland, Biochemical, Extracellular Matrix Proteins.
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