By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Nanoparticles have been presented. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "To investigate a fatty acid-based strategy for efficient brain targeted gene delivery and to understand mechanism(s) of this small molecule-mediated brain gene delivery strategy. A series of fatty acids (FAs) were conjugated with polyethylenimine (PEI25k)."
Our news journalists obtained a quote from the research from Fudan University, "A near-infrared fluorescence probe, IR820, was used to study in vivo and ex vivo brain targeting ability of these fatty acid-PEI conjugates (FA-PEIs). Brain uptake of FA-PEI25k/rhodamine-6-isothiocyanate (RITC)-labeled DNA nanoparticles was investigated via a fluorescence imaging method. Moreover, pEGFP was used as a model gene to study in vitro and in vivo transfection effect of the ideal FA-PEI25k conjugate. FA modification did not have interference with the complexation between DNA and the PEI25k. The FA-PEI25k conjugates showed excellent brain targeting ability compared with unmodified PEI25k. Among these FA-PEI25k conjugates studied, myristic acid (MC)-PEI25k showed sustained brain distribution profile and higher brain DNA uptake. Furthermore, MC-PEI(25k/)pEGFP nanoparticles was able to achieve efficient in vitro and in vivo gene transfection. GFP expression was observed at different brain regions in vivo."
According to the news editors, the research concluded: "These results demonstrated that the small molecule fatty acid, particularly myristic acid-based brain gene delivery strategy, is promising to mediate efficient gene transfection in the brain."
For more information on this research see: Fatty Acid-Based Strategy for Efficient Brain Targeted Gene Delivery. Pharmaceutical Research, 2013;30(10):2573-2583. Pharmaceutical Research can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Pharmaceutical Research - www.springerlink.com/content/0724-8741/)
Our news journalists report that additional information may be obtained by contacting J. Shen, Fudan University, Minist Educ, Key Lab Mol Engn Polymers, Shanghai 200433, People's Republic of China. Additional authors for this research include M. Yu, Q.G. Meng, J. Li, Y.F. Lv and W.Y. Lu (see also Nanoparticles).
Keywords for this news article include: Asia, Shanghai, Nanotechnology, Emerging Technologies, People's Republic of China
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