By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies. According to news reporting out of Toledo, Ohio, by NewsRx editors, research stated, "To formulate nanoemulsions (NE) with potential for delivering poorly water-soluble drugs to the lungs. A self nanoemulsifying composition consisting of cremophor RH 40, PEG 400 and labrafil M 2125 CS was selected after screening potential excipients."
Our news journalists obtained a quote from the research from the University of Toledo, "The solubility of carbamazepine, a poorly water-soluble drug, was tested in the formulation components. Oil-in-water (o/w) NEs were characterized using dynamic light scattering, electrophoretic light scattering, transmission electron microscopy (TEM) and differential scanning calorimetry. NEs were nebulized into a mist using a commercial nebulizer and characterized using laser diffraction and TEM. An aseptic method was developed for preparing sterile NEs. Biocompatibility of the formulation was evaluated on NIH3T3 cells using MTT assay. In vitro permeability of the formulation was tested in zebra fish eggs, HeLa cells, and porcine lung tissue. NEs had neutrally charged droplets of less than 20 nm size. Nebulized NEs demonstrated an o/w nanostructure. The mist droplets were of size less than 5 mu m. Sterility testing and cytotoxicity results validated that the NE was biocompatible and sterile. In vitro tests indicated oil nanodroplets penetrating intracellularly through biological membranes."
According to the news editors, the research concluded: "The nanoemulsion mist has the potential for use as a pulmonary delivery system for poorly water-soluble drugs."
For more information on this research see: Development and Characterization of Nanostructured Mists with Potential for Actively Targeting Poorly Water-Soluble Compounds into the Lungs. Pharmaceutical Research, 2013;30(10):2625-2639. Pharmaceutical Research can be contacted at: Springer, Plenum Publishers, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Pharmaceutical Research - www.springerlink.com/content/0724-8741/)
Our news journalists report that additional information may be obtained by contacting J. Nesamony, Univ Toledo HSC, Coll Pharm & Pharmaceut Sci, Div Ind Pharm, Dept. of Pharm Practice, Toledo, OH 43614, United States. Additional authors for this research include A. Kalra, M.S. Majrad, S.H.S. Boddu, R. Jung, F.E. Williams, A.M. Schnapp, S.M. Nauli and A.L. Kalinoski (see also Drugs and Therapies).
Keywords for this news article include: Ohio, Toledo, United States, Drugs and Therapies, North and Central America
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