By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Current study results on Angioplasty have been published. According to news reporting originating in Jerusalem, Israel, by NewsRx journalists, research stated, "Cardiovascular diseases (CVD) are one of the leading causes of death across the globe. Pathogenesis of coronary artery disease (CAD) is lead by the progression of atherosclerotic lacerations in coronary arteries."
The news reporters obtained a quote from the research from Hebrew University, "Percutaneous coronary intervention (PCI) using balloon angioplasty was introduced in 1979 and was majorly used in the treatment of these lesions. Introduction of bare metal stents (BMS) has revolutionized stenting procedures overcoming elastic recoil and reducing restenosis commonly associated with balloon angioplasty, but follow up studies have shown 20-30% prevalence of in-stent restenosis (ISR), this led to the development of drug eluting stents (DES). But long-term follow up studies have shown increased liability of stent thrombosis. Boosting the development of safer and effective DES expounding for therapies like biodegradable polymer based DES, polymer free DES, bioresorbable DES and combination DES to collectively reduce neointimal hyperplasia and promote endothelial healing. In dual-DES development, a combination employing an anti-restenotic agent (for preventing VSMC's proliferation), which is released for the first few weeks, and then the second drug a pro-healing agent (promoting re-endothelialization) released after a month would be ideal."
According to the news reporters, the research concluded: "Growing understanding in the areas of polymer therapeutics, nanoscale surface modifications and gene therapy would assist in the delivery of multiple drugs, which would further help in the design of promising therapeutic strategies for the treatment of CAD using stent based therapies."
For more information on this research see: Eluting combination drugs from stents. International Journal of Pharmaceutics, 2013;454(1):4-10. International Journal of Pharmaceutics can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news correspondents report that additional information may be obtained by contacting R. Thipparaboina, Hebrew University of Jerusalem, Fac Med, Sch Pharm, Inst Drug Res, IL-91120 Jerusalem, Israel. Additional authors for this research include W. Khan and A.J. Domb (see also Angioplasty).
Keywords for this news article include: Asia, Biotechnology, Israel, Surgery, Jerusalem, Treatment, Angioplasty, Gene Therapy, Bioengineering, Vascular Surgical Procedures
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