By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Proteins. According to news originating from San Francisco, California, by NewsRx correspondents, research stated, "Repair of peripheral nerve defects with current synthetic, tubular nerve conduits generally shows inferior recovery when compared with using nerve autografts, the current gold standard. We tested the ability of composite collagen and hyaluronan hydrogels, with and without the nerve growth factor (NGF), to stimulate neurite extension on a promising aligned, nanofiber poly-L-lactide-co-caprolactone (PLCL) scaffold."
Our news journalists obtained a quote from the research from Veterans Affairs Medical Center, "In vitro, the hydrogels significantly increased neurite extension from dorsal root ganglia explants. Consistent with these results, the addition of hydrogels as luminal fillers within aligned, nanofiber tubular PLCL conduits led to improved sensory function compared to autograft repair in a critical-size defect in the sciatic nerve in a rat model. Sensory recovery was assessed 3 and 12 weeks after repair using a withdrawal assay from thermal stimulation. The addition of hydrogel did not enhance recovery of motor function in the rat model. The NGF led to dose-dependent improvements in neurite out-growth in vitro, but did not have a significant effect in vivo. In summary, composite collagen/hyaluronan hydrogels enhanced sensory neurite outgrowth in vitro and sensory recovery in vivo."
According to the news editors, the research concluded: "The use of such hydrogels as luminal fillers for tubular nerve conduits may therefore be useful in assisting restoration of protective sensation following peripheral nerve injury."
For more information on this research see: Peripheral Nerve Repair in Rats Using Composite Hydrogel-Filled Aligned Nanofiber Conduits with Incorporated Nerve Growth Factor. Tissue Engineering Part A, 2013;19(19-20):2138-2146. Tissue Engineering Part A can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA (see also Proteins).
The news correspondents report that additional information may be obtained from J. Jin, San Francisco VA Med Center, San Francisco, CA, United States. Additional authors for this research include S. Limburg, S.K. Joshi, R. Landman, M. Park, Q. Zhang, H.T. Kim and A.C. Kuo.
Keywords for this news article include: Alcohols, Hydrogel, California, San Francisco, United States, Organic Chemicals, Nerve Growth Factors, Polyethylene Glycols, Nerve Tissue Proteins, North and Central America, Intercellular Signaling Peptides and Proteins
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