Our news editors obtained a quote from the research, "In oxygen-saturated pH = 9.0 Tris-HCl buffer, a strong ECL emission of QDs could be observed during the cathodic process due to the H2O2 product from electrochemical reduction of dissolved oxygen. Upon the formation of immunocomplex, the second antibody labeled with horseradish peroxidase was simply immobilized on the electrode surface. The ECL emission decreased since steric hindrance of the immunocomplex slowed down the electron-transfer speed of dissolved oxygen, and also could be greatly amplified by an enzymatic cycle to consume the self-produced coreactant. Using clenbuterol as model analyte, the ECL intensity was determined by the concentration of competitive immunoassay of clenbuterol with a wide calibration in the range of 0.05 ng mL(-1) to 1000 ng mL(-1), and a low detection limit was 0.02 ng mL(-1). The immunosensor shows good stability and fabrication reproducibility. It was applied to detecting practical samples with the satisfactory results."
According to the news editors, the research concluded: "This immunosensing strategy opens a new avenue for detection of residue and application of QDs in ECL biosensing."
For more information on this research see: Quantum dots based electrochemiluminescent immunosensor by coupling enzymatic amplification for ultrasensitive detection of clenbuterol. Analytica Chimica Acta, 2013;798():82-88. Analytica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae
The news editors report that additional information may be obtained by contacting X. Yao, Key Lab Hlth Chem & Mol Diag Suzhou,
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