By a News Reporter-Staff News Editor at Science Letter -- Research findings on Immunology are discussed in a new report. According to news reporting originating from La Jolla, California, by NewsRx correspondents, research stated, "Innate-like natural killer T (NKT) cells critically enhance cell and humoral immunity against infections through recognition of conserved microbial lipid antigens presented by CD1d-expressing antigen-presenting cells, and provision of CD40L and cytokine signals. Whereas NKT cells efficiently licensed dendritic cells to prime potent effector and memory T cells, studies based on model antigens such as alphagalactosylceramide-nitrophenyl conjugates concluded that help to B cells was associated with NKT follicular helper differentiation, but limited to short-term responses without induction of memory."
Our news editors obtained a quote from the research from Scripps Research Institute, "We revisited this surprising conclusion in the context of the extracellular encapsulated pathogen Streptococcus pneumoniae, where recognition of lipid and capsular polysaccharide antigens by NKT cells and B cells, respectively, provide critical host protection. Using liposomal nanoparticles displaying synthetic lipid and polysaccharide antigens to elicit pure and direct NKT-B-cell interactions in vivo, we observed intense and prolonged antibody responses with isotype switch, affinity maturation, and long-lasting B-cell memory, despite modest or absent NKT follicular helper differentiation. Furthermore, conditional ablation of Cd1d demonstrated a requirement for a two-step process involving first cognate interactions with dendritic cells, for NKT cell activation, and then with B cells, for induction of isotype switch and memory."
According to the news editors, the research concluded: "Thus, NKT help to B cells represents both a major arm of antimicrobial defense and a promising target for B-cell vaccines."
For more information on this research see: Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(40):16097-16102. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
The news editors report that additional information may be obtained by contacting L. Bai, Scripps Res Inst, Dept. of Immunol, La Jolla, CA 92037, United States. Additional authors for this research include S.L. Deng, R. Reboulet, R. Mathew, L. Teyton, P.B. Savage and A. Bendelac (see also Immunology).
Keywords for this news article include: Antibodies, Antigen-Presenting Cells, La Jolla, California, Immunology, United States, Blood Proteins, Dendritic Cells, Immunoglobulins, Biological Factors, North and Central America, Mononuclear Phagocyte System
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