"Our technique of employing SAXS with gold nanolabels allows us to examine DNA processing by cooperative enzymes in which solution conditions, long distances, low concentrations, substoichiometric populations, and short time-scales are of importance," says
the MutS protein will bind to a mismatched DNA site by bending the DNA. ATP enzymes will come in to encircle and excise the error. The MutS then straightens out the bend and continues to proofread the DNA.
"This is the first time we used this technique to look at a protein-mediated process like DNA repair in solution with multiple partners," Hura says. "We were able to determine some important details about MutS and the MMR system that should be valuable for drug design. We also now know what to look for in cancer-causing mutations of MutS. When we look at mutant versions of MutS we may be able to see that they do not bend the DNA or form the filament to the same extent as the normal version."
Keywords for this news article include: DNA Repair, Proteomics,
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC
Most Popular Stories
- 2014 Will Be 'Breakthrough Year' for U.S., Obama Says
- Prius Among Insurance Institute's 39 Top Safety Vehicles
- Target Overwhelmed by Worried Customers
- Congress Ends Turbulent Year with Approving IRS Chief
- First Family Arrives for Hawaiian Island Holiday
- Renewable Energy Group to Acquire Syntroleum
- Ally Financial Settles Auto Loan Suit
- Covered California Lags on Hispanic Enrollment
- Climate Change Isn't an Equal Opportunity Destroyer
- Chris Christie Set to Sign Tuition Aid Bill