By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on DNA Research have been presented. According to news reporting originating from Augusta, Georgia, by NewsRx correspondents, research stated, "Cytosolic DNA sensing via the stimulator of IFN genes (STING) adaptor incites autoimmunity by inducing type I IFN (IFN-alpha beta). In this study, we show that DNA is also sensed via STING to suppress immunity by inducing IDO."
Our news editors obtained a quote from the research from the Department of Pediatrics, "STING gene ablation abolished IFN-alpha beta and IDO induction by dendritic cells (DCs) after DNA nanoparticle (DNP) treatment. Marginal zone macrophages, some DCs, and myeloid cells ingested DNPs, but CD11b(+) DCs were the only cells to express IFN-beta, whereas CD11b(+) non-DCs were major IL-1 beta producers. STING ablation also abolished DNP-induced regulatory responses by DCs and regulatory T cells, and hallmark regulatory responses to apoptotic cells were also abrogated. Moreover, systemic cyclic diguanylate monophosphate treatment to activate STING induced selective IFN-beta expression by CD11b(+) DCs and suppressed Th1 responses to immunization."
According to the news editors, the research concluded: "Thus, previously unrecognized functional diversity among physiologic innate immune cells regarding DNA sensing via STING is pivotal in driving immune responses to DNA."
For more information on this research see: Cutting Edge: DNA Sensing via the STING Adaptor in Myeloid Dendritic Cells Induces Potent Tolerogenic Responses. Journal of Immunology, 2013;191(7):3509-3513. Journal of Immunology can be contacted at: Amer Assoc Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. (The American Association of Immunologists - www.aai.org; Journal of Immunology - www.jimmunol.org)
The news editors report that additional information may be obtained by contacting L. Huang, Georgia Regents Univ, Dept. of Pediat, Augusta, GA 30912, United States. Additional authors for this research include L.Q. Li, H. Lemos, P.R. Chandler, G. Pacholczyk, B. Baban, G.N. Barber, Y. Hayakawa, T.L. McGaha, B. Ravishankar, D.H. Munn and A.L. Mellor (see also DNA Research).
Keywords for this news article include: Antigen-Presenting Cells, Augusta, Georgia, Treatment, Immunology, DNA Research, United States, Dendritic Cells, North and Central America, Mononuclear Phagocyte System
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