By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Fresh data on Stargardt Disease are presented in a new report. According to news reporting originating from Vienna, Austria, by NewsRx correspondents, research stated, "To identify disease-specific changes in Stargardt disease (STGD) based on imaging with polarization-sensitive spectral-domain optical coherence tomography (PS-OCT) and to compare structural changes with those visible on blue light fundus autofluorescence (FAF) imaging. Twenty-eight eyes of 14 patients diagnosed with STGD were imaged using a novel high-speed, large-field PS-OCT system and FAF (excitation 488 nm, emission > 500 nm)."
Our news editors obtained a quote from the research from Medical University, "The ophthalmoscopic phenotype was classified into three groups. ABCA4 mutation testing detected 15 STGD alleles, six of which harbor novel mutations. STGD phenotype 1 (12 eyes) showed sharply delineated areas of absent RPE signal on RPE segmentation B-scans of PS-OCT correlating with areas of hypofluorescence on FAF. Adjacent areas of irregular fluorescence correlated with an irregular RPE segmentation line with absence of overlaying photoreceptor layers. Eyes characterized on OCT by a gap in the subfoveal outer segment layer (foveal cavitation) showed a normal RPE segmentation line on PS-OCT. Hyperfluorescent flecks on FAF in phenotype 2 STGD (8 eyes) were identified as clusters of depolarizing material at the level of the RPE. Distribution of flecks could be depicted on RPE elevation maps. An increased amount of depolarizing material in the choroid was characteristic for STGD Phenotype 3 (8 eyes). PS-OCT together with FAF identified characteristic patterns of changes in different stages of the disease."
According to the news editors, the research concluded: "PS-OCT is a promising new tool for diagnosis and evaluation of future treatment modalities in STGD."
For more information on this research see: Characterization of Stargardt Disease Using Polarization-Sensitive Optical Coherence Tomography and Fundus Autofluorescence Imaging. Investigative Ophthalmology & Visual Science, 2013;54(9):6416-6425. Investigative Ophthalmology & Visual Science can be contacted at: Assoc Research Vision Ophthalmology Inc, 12300 Twinbrook Parkway, Rockville, MD 20852-1606, USA. (The Association for Research in Vision and Ophthalmology - www.arvo.org; Investigative Ophthalmology & Visual Science - www.iovs.org/)
The news editors report that additional information may be obtained by contacting M. Ritter, Medical University of Vienna, Dept. of Neuromuscular Res, Center Anat & Cell Biol, A-1090 Vienna, Austria. Additional authors for this research include S. Zotter, W.M. Schmidt, R.E. Bittner, G.G. Deak, M. Pircher, S. Sacu, C.K. Hitzenberger and U.M. Schmidt-Erfurth (see also Stargardt Disease).
Keywords for this news article include: Vienna, Europe, Austria, Genetics, Stargardt Disease, Imaging Technology, Macular Degeneration, Optical Coherence Tomography
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