technology Research Center Update Understanding of Rheumatoid Arthritis -->
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Autoimmune Diseases. According to news reporting originating from Shandong, People's Republic of China, by NewsRx correspondents, research stated, "PSORS1C1/CDSN is a susceptibility gene for psoriasis. Both psoriasis and rheumatoid arthritis (RA) are autoimmune diseases."
Our news editors obtained a quote from the research from Biotechnology Research Center, "This study investigated whether PSORS1C1 /CDSN was involved in RA. The TagSNPs rs3130983, rs3778638 and rs4959053 in the PSORS1C1/CDSN locus were shown to predict susceptibility to RA in two independent RA cohorts using a TaqMan genotyping assay and Sequenom MassARRAY. The expression of PSORS1C1/CDSN was determined with western blotting and ELISA. Cultured synovial fibroblasts from RA patients (RASF) were treated with anti-PSORS1C1 siRNA. The TaqMan genotyping assay demonstrated significant differences in the rs3130983 and rs4959053 allele frequencies (p = 0.002001 and 1.74E-07, respectively) and genotype frequencies (0.010503 and 1.07E-06, respectively) between the RA patients and controls. Sequenom MassARRAY results indicated that SNP rs3778638 allele frequency and genotype frequency were significantly associated with RA (p = 7.35E-05 and 0.000357, respectively). Western blotting revealed a significant increase in expression of PSORS1C1 in RA synovial tissues, and ELISA detected high levels of PSORS1C1 and CDSN in the blood of RA patients."
According to the news editors, the research concluded: "PSORS1C1-siRNA treatment significantly decreased the PSORS1C1 expression, IL-17 level, 11-1 beta level and cell proliferation in RASE These results suggest that PSORS1C1 might play an important role in the development of RA."
For more information on this research see: PSORS1C1 may be involved in rheumatoid arthritis. Immunology Letters, 2013;153(1-2):9-14. Immunology Letters can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Immunology Letters - www.elsevier.com/wps/product/cws_home/506020)
The news editors report that additional information may be obtained by contacting H.J. Sun, Shandong Academy Med Sci, Medical Biotechnol Res Center, Jinan 250062, Shandong, People's Republic of China. Additional authors for this research include Y.F. Xia, L. Wang, Y.J. Wang and X.T. Chang (see also Autoimmune Diseases).
Keywords for this news article include: Asia, Shandong, Joint Diseases, Autoimmune Diseases, Rheumatoid Arthritis, Musculoskeletal Diseases, People's Republic of China
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