By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Fresh data on Nervous System Diseases and Conditions are presented in a new report. According to news reporting out of Boston, Massachusetts, by NewsRx editors, research stated, "Microglia are resident immune cells of the CNS that are activated by infection, neuronal injury, and inflammation. Here, we utilize flow cytometry and deep RNA sequencing of acutely isolated spinal cord microglia to define their activation in vivo."
Our news journalists obtained a quote from the research from the Harvard University School of Medicine, "Analysis of resting microglia identified 29 genes that distinguish microglia from other CNS cells and peripheral macrophages/monocytes. We then analyzed molecular changes in microglia during neurodegenerative disease activation using the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). We found that SOD1(G93A) microglia are not derived from infiltrating monocytes, and that both potentially neuroprotective and toxic factors, including Alzheimer's disease genes, are concurrently upregulated. Mutant microglia differed from SOD1(WT), lipopolysaccharide-activated microglia, and M1/M2 macrophages, defining an ALS-specific phenotype. Concurrent messenger RNA/fluorescence-activated cell sorting analysis revealed posttranscriptional regulation of microglia surface receptors and T cell-associated changes in the transcriptome."
According to the news editors, the research concluded: "These results provide insights into microglia biology and establish a resource for future studies of neuroinflammation."
For more information on this research see: A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Reports, 2013;4(2):385-401. (Elsevier - www.elsevier.com; Cell Reports - www.elsevier.com/wps/product/cws_home/727006)
Our news journalists report that additional information may be obtained by contacting I.M. Chiu, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. Additional authors for this research include E.T. Morimoto, H. Goodarzi, J.T. Liao, S. O'Keeffe, H.P. Phatnani, M. Muratet, M.C. Carroll, S. Levy, S. Tavazoie, R.M. Myers and T. Maniatis (see also Nervous System Diseases and Conditions).
Keywords for this news article include: Boston, Genetics, Microglia, Monocytes, Neuroglia, Neurology, Immunology, Blood Cells, Macrophages, Massachusetts, United States, Mental Health, Bone Marrow Cells, Motor Neuron Disease, Spinal Cord Diseases, Mononuclear Leukocytes, Neuromuscular Diseases, TDP 43 Proteinopathies, Hemic and Immune Systems.
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