By a News Reporter-Staff News Editor at Clinical Trials Week -- Fresh data on Central Nervous System are presented in a new report. According to news reporting from Chemnitz, Germany, by NewsRx journalists, research stated, "Intraoperative optical imaging (IOI) is an experimental technique used for visualizing functional brain areas after surgical exposure of the cerebral cortex. This technique identifies areas of local changes in blood volume and oxygenation caused by stimulation of specific brain functions."
The news correspondents obtained a quote from the research from the Department of Neurosurgery, "The authors describe a new JOT method, including innovative data analysis, that can facilitate intraoperative functional imaging on a routine basis. To evaluate the reliability and validity of this approach, they used the new IOI method to demonstrate visualization of the median nerve area of the somatosensory cortex. In 41 patients with tumor lesions adjacent to the postcentral gyrus, lesions were surgically removed by using TOT during stimulation of the contralateral median nerve. Optical properties of the cortical tissue were measured with a sensitive camera system connected to a surgical microscope Imaging was performed by using 9 cycles of alternating prolonged stimulation and rest periods of 30 seconds. Intraoperative optical imaging was based on blood volume changes detected by using a filter at an isosbestic wavelength (lambda = 568 nm). A spectral analysis algorithm was used to improve computation of the activity maps. Movement artifacts were compensated for by an elastic registration algorithm. For validation, intraoperative conduction of the phase reversal over the central sulcus and postoperative evaluation of the craniotomy site were used. The new method and analysis enabled significant differentiation (p < 0.005) between functional and nonfunctional tissue. The identification and visualization of functionally intact somatosensory cortex was highly reliable; sensitivity was 94.4% and specificity was almost 100%. The surgeon was provided with a 2D high-resolution activity map within 12 minutes. No method-related side effects occurred in any of the 41 patients. The authors' new approach makes IOI a contact-free and label-free optical technique that can be used safely in a routine clinical setup. Intraoperative optical imaging can be used as an alternative to other methods for the identification of sensory cortex areas and offers the added benefit of a high-resolution map of functional activity. It has great potential for visualizing and monitoring additional specific functional brain areas such as the visual, motor, and speech cortex."
According to the news reporters, the research concluded: "A prospective national multicenter clinical trial is currently being planned."
For more information on this research see: Intraoperative optical imaging of intrinsic signals: a reliable method for visualizing stimulated functional brain areas during surgery Clinical article. Journal of Neurosurgery, 2013;119(4):853-863. Journal of Neurosurgery can be contacted at: Amer Assoc Neurological Surgeons, 5550 Meadowbrook Drive, Rolling Meadows, IL 60008, USA (see also Central Nervous System).
Our news journalists report that additional information may be obtained by contacting S.B. Sobottka, Klinikum Chemnitz gGmbH, Dept. of Neurosurg, Chemnitz, Germany. Additional authors for this research include T. Meyer, M. Kirsch, E. Koch, R. Steinmeier, U. Morgenstern and G. Schackert.
Keywords for this news article include: Europe, Germany, Surgery, Chemnitz, Algorithms, Central Nervous System, Clinical Trials and Studies
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