By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting from Tianjin, People's Republic of China, by NewsRx journalists, research stated, "Nanomaterials and relevant products are now being widely used in the world, and their safety becomes a great concern for the general public. Tungsten carbide nanoparticles (nano-WC) are widely used in metallurgy, aeronautics and astronautics, however our knowledge regarding the influence of nano-WC on neurons is still lacking."
The news correspondents obtained a quote from the research from Nankai University, "The aim of this study was to investigate the impact of nano-WC on tetrodotoxin (TTX)-sensitive voltage-activated sodium current (I(Na)) of hippocampal CA1 pyramidal neurons. Results showed that acute exposure of nano-WC attenuated the peak amplitudes of I(Na) in a concentration-dependent manner. The minimal effective concentration was 10(-5)g/ml. The exposure of nano-WC significantly decreased current amplitudes of the current-voltage curves of I(Na) from -50 to+50 mV, shifted the steady-state activation and inactivation curves of I(Na) negatively and delayed the recovery of I(Na) from inactivation state. After exposure to nano-WC, the peak amplitudes, overshoots and the V-thresholds of action potentials (APs) were markedly reduced."
According to the news reporters, the research concluded: "These results suggested that exposure of nano-WC could influence some characteristics of APs evoked from the hippocampal CA1 neurons by modifying the kinetics of voltage-gated sodium channels (VGSCs)."
For more information on this research see: Attenuated effect of tungsten carbide nanoparticles on voltage-gated sodium current of hippocampal CA1 pyramidal neurons. Toxicology In Vitro, 2013;27(1):299-304. (Elsevier - www.elsevier.com; Toxicology In Vitro - www.elsevier.com/wps/product/cws_home/800)
Our news journalists report that additional information may be obtained by contacting D. Shan, College of Medicine Science, Nankai University, Tianjin 300071, People's Taiwan. Additional authors for this research include Y. Xie, G. Ren and Z. Yang (see also Nanoparticles).
Keywords for this news article include: Asia, Tianjin, Chemicals, Chemistry, Nanotechnology, Tungsten Carbide, Transition Elements, Emerging Technologies, People's Republic of China.
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