By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Keto Acids. According to news reporting out of Jiangsu, People's Republic of China, by NewsRx editors, research stated, "Candida glabrata has been recognized as an efficient industrial microorganism for the production of pyruvate, the most widely used ?-oxocarboxylic acid in the areas of agrochemicals, drugs, and chemicals. To gain a comprehensive understanding of its physiology and cellular metabolism, the genome-scale metabolic model for C. glabrata (named iNX804), comprising 804 genes, 1287 reactions, and 1025 metabolites, was reconstructed by genome sequence annotation and biochemical data mining."
Our news journalists obtained a quote from the research from Jiangnan University, "The flux balance analysis data of model iNX804 exhibited good agreement with the experimental data, including the phenotypic data and the carbon flux distribution. The model iNX804 predicted that C. glabrata can synthesize a high concentration of pyruvate because it has a strong glucose transport capacity and three pyruvate biosynthesis pathways and is deficient in key steps in vitamin synthesis. Furthermore, the metabolic capacity of pyruvate and other fine chemicals derived from pyruvate was evaluated by in silico deletion and overexpression of several key genes."
According to the news editors, the research concluded: "The metabolic model iNX804 provides a potential platform for global elucidation of the metabolism of C."
For more information on this research see: Reconstruction and analysis of the genome-scale metabolic network of Candida glabrata. Molecular Biosystems, 2013;9(2):205-16. (Royal Society of Chemistry - www.rsc.org/; Molecular Biosystems - pubs.rsc.org/en/journals/journalissues/mb)
Our news journalists report that additional information may be obtained by contacting N. Xu, State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, People's Taiwan. Additional authors for this research include L. Liu, W. Zou, J. Liu, Q. Hua and J. Chen (see also Keto Acids).
Keywords for this news article include: Asia, Jiangsu, Chemicals, Chemistry, Pyruvates, Keto Acids, People's Republic of China.
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