By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteins have been published. According to news reporting originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "During cancer development, the fibrous layers surrounding the tumor surface get thin and stiff which facilitates the tumor metastasis. After the treatment of metallofullerene derivatives Gd@C82(OH)22, the fibrous layers become thicker and softer, the metastasis of tumor is then largely suppressed."
Our news editors obtained a quote from the research from the Institute of High Energy Physics, "The effect of Gd@C82(OH)22 was found to be related to their direct interaction with collagen and the resulting impact on the structure of collagen fibrils, the major component of extracellular matrices. In this work we study the interaction of Gd@C82(OH)22 with collagen by molecular dynamics simulations. We find that Gd@C82(OH)22 can enhance the rigidity of the native structure of collagen molecules and promote the formation of an oligomer or a microfibril. The interaction with Gd@C82(OH)22 may regulate further the assembly of collagen fibrils and change the biophysical properties of collagen. The control run with fullerene derivatives C60(OH)24 also indicates that C60(OH)24 can influence the structure and assembly of collagen molecules as well, but to a lesser degree. Both fullerene derivatives can form hydrogen bonds with multiple collagen molecules acting as a 'fullerenol-mediated bridge' that enhance the interaction within or among collagen molecules."
According to the news editors, the research concluded: "Compared to C60(OH)24, the interaction of Gd@C82(OH)22 with collagen is stronger, resulting in particular biomedical effects for regulating the biophysical properties of collagen fibrils."
For more information on this research see: Impacts of fullerene derivatives on regulating the structure and assembly of collagen molecules. Nanoscale, 2013;5(16):7341-8. (Royal Society of Chemistry - www.rsc.org/; Nanoscale - pubs.rsc.org/en/journals/journalissues/nr)
The news editors report that additional information may be obtained by contacting X. Yin, CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, People's Taiwan. Additional authors for this research include L. Zhao, S.G. Kang, J. Pan, Y. Song, M. Zhang, G. Xing, F. Wang, J. Li, R. Zhou and Y. Zhao (see also Proteins).
Keywords for this news article include: Asia, Carbon, Beijing, Collagen, Fullerenes, Nanotechnology, Emerging Technologies, People's Republic of China, Extracellular Matrix Proteins.
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