By a News Reporter-Staff News Editor at Diabetes Week -- Data detailed on Peptide Proteins have been presented. According to news reporting from Shanghai, People's Republic of China, by NewsRx journalists, research stated, "This study aimed to prepare nanoemulsions coated with alginate/chitosan for oral insulin delivery. Uncoated nanoemulsions were prepared by homogenization of a water in oil in water (w/o/w) multiple emulsion that was composed of Labrafac(®) CC, phospholipid, Span™ 80 and Cremorphor(®) EL."
The news correspondents obtained a quote from the research from Fudan University, "Coating of the nanoemulsions was achieved based on polyelectrolyte cross-linking, with sequential addition of calcium chloride and chitosan to the bulk nanoemulsion dispersion that contained alginate. The particle size of the coated nanoemulsions was about 488 nm and the insulin entrapment ratio was 47.3%. Circular dichroism spectroscopy proved conformational stability of insulin against the preparative stress. In vitro leakage study indicated well-preserved integrity of the nanoemulsions in simulated gastric juices. Hypoglycemic effects were observed in both normal and diabetic rats. The relative pharmacological bioavailability of the coated nanoemulsion with 25 and 50 IU/kg insulin were 8.42% and 5.72% in normal rats and 8.19% and 7.84% in diabetic rats, respectively. Moreover, there were significantly prolonged hypoglycemic effects after oral administration of the coated nanoemulsions compared with subcutaneous (sc) insulin."
According to the news reporters, the research concluded: "The nanoemulsion coated with alginate/chitosan was a potential delivery system for oral delivery of polypeptides and proteins."
For more information on this research see: Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats. International Journal of Nanomedicine, 2013;8():23-32 (see also Peptide Proteins).
Our news journalists report that additional information may be obtained by contacting X. Li, Key Laboratory of Smart Drug Delivery of Ministry of Education and People's Liberation Army (PLA), School of Pharmacy, Fudan University, Shanghai, People's Taiwan. Additional authors for this research include J. Qi, Y. Xie, X. Zhang, S. Hu, Y. Xu, Y. Lu and W. Wu.
Keywords for this news article include: Asia, Shanghai, Proinsulin, Nanoemulsion, Nanotechnology, Peptide Hormones, Peptide Proteins, Emerging Technologies, People's Republic of China.
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