By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Stem Cell Research. According to news reporting from Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "To investigate the synergistic effect of IL-1Ra administration and stem cell transplantation in swine suffering from acute liver failure (ALF), to elucidate the mechanism of IL-1Ra activity and to demonstrate mesenchymal stem cell (MSC) transplantation as a potential treatment for ALF. Thirty-five Chinese experimental mini-swine were divided into five groups randomly."
The news correspondents obtained a quote from the research from Southeast University, "Group A (n = 7) is the control group and all swine were injected with saline via portal veins. Group B (n = 7) received IL-1Ra via ear veins 6 h before receiving saline. Group C (n = 7) received MSC transplantation and all swine were injected with 8 x 10(7) MSCs via portal veins. Group D (n = 7) swine were treated with a combination of IL-1Ra and MSC transplantation E (n = 7) also received a combined treatment of both IL-1Ra and bone marrow (BM-MSC) transplantation, except that the IL-1Ra was in the form of chitosan nanoparticles. Liver function, level of cytokines and liver pathological changes were measured in the following 4 weeks. IL-1Ra chitosan nanoparticles exhibited controlled-release ability in PBS. Swine in Group E showed a significant improvement in inflammation environment, liver function and hepatocyte proliferation. Levels of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) in Group E were elevated compared to other groups. IL-1Ra chitosan nanoparticles showed significant liver targeting ability and controlled-release characteristics."
According to the news reporters, the research concluded: "Combined therapy with IL-1Ra chitosan nanoparticles and MCS transplantation exhibits great synergistic effects through paracrine function and suppression of inflammation."
For more information on this research see: Administration of IL-1Ra Chitosan Nanoparticles Enhances the Therapeutic Efficacy of Mesenchymal Stem Cell Transplantation in Acute Liver Failure. Archives of Medical Research, 2013;44(5):370-379. Archives of Medical Research can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Archives of Medical Research - www.elsevier.com/wps/product/cws_home/601442)
Our news journalists report that additional information may be obtained by contacting J.Q. Xiao, Southeast Univ, Sch Public Hlth, Nanjing, Jiangsu, People's Republic of China. Additional authors for this research include X.L. Shi, H.C. Ma, J.J. Tan, Lin-zhang, Q. Xu and Y.T. Ding (see also Stem Cell Research).
Keywords for this news article include: Asia, Jiangsu, Surgery, Treatment, Hepatology, Nanoparticle, Liver Diseases, Nanotechnology, Gastroenterology, Stem Cell Research, Acute Liver Failure, Emerging Technologies, Hepatic Insufficiency, People's Republic of China, Clinical Trials and Studies, Mesenchymal Stem Cell Transplantation
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