By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Myeloid Cells is the subject of a report. According to news reporting originating in Lodz, Poland, by NewsRx journalists, research stated, "Hydrolyzable tannins are known to exhibit diverse biological effects, which can be used in combination with silver nanoparticles (AgNPs). In this study, we tested toxic and inflammatory properties of tannic-acid modified 13, 33, 46 nm and unmodified 10-65 nm AgNPs using murine 291.03C keratinocyte and RAW 264.7 monocyte cell lines."
The news reporters obtained a quote from the research from the University of Lodz, "Both cell lines exposed for 24 h to 1-10 mu/ml of 13 nm, 33 nm, 46 nm and unmodified AgNPs showed dose-dependent toxicity and decreased cell proliferation. Only small-sized AgNPs induced production of ROS by monocytes, but not keratinocytes. Monocytes internalized large aggregates of 33,46 nm and 10-65 nm AgNPs in cytoplasmic vacuoles, whereas keratinocytes accumulated less particles. AgNPs of 13 nm were localized ubiquitously within both cell types. The tested AgNPs strongly down-regulated production of tumor necrosis factor-alpha (TNF-alpha) by monocytes, whereas keratinocytes exposed to AgNPs showed an opposite effect. Unmodified but not tannic acid-modified AgNPs increased production of the pro-inflammatory MCP-1 by monocytes and keratinocytes."
According to the news reporters, the research concluded: "In summary, low inflammatory potential and lack of ROS production by tannic-acid modified AgNPs sized above 30 nm suggests that tannic acid modification of large silver nanoparticles may help to increase AgNPs biosafety."
For more information on this research see: Assessment of in vitro cellular responses of monocytes and keratinocytes to tannic acid modified silver nanoparticles. Toxicology in Vitro, 2013;27(6):1798-1808. Toxicology in Vitro can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Toxicology in Vitro - www.elsevier.com/wps/product/cws_home/800)
Our news correspondents report that additional information may be obtained by contacting P. Orlowski, University of Lodz, Dept. of Mat Technol & Chem, PL-90236 Lodz, Poland. Additional authors for this research include M. Krzyzowska, R. Zdanowski, A. Winnicka, J. Nowakowska, W. Stankiewicz, E. Tomaszewska, G. Celichowski and J. Grobelny (see also Myeloid Cells).
Keywords for this news article include: Lodz, Poland, Europe, Monocytes, Immunology, Blood Cells, Nanoparticle, Keratinocytes, Myeloid Cells, Nanotechnology, Epithelial Cells, Bone Marrow Cells, Emerging Technologies, Mononuclear Leukocytes, Hemic and Immune Systems, Mononuclear Phagocyte System
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