By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting originating from Tabriz, Iran, by NewsRx correspondents, research stated, "Telomerase has been considered as an attractive molecular target for breast cancer therapy. The main objective of this work is to assess the inhibitory effects of silibinin and curcumin, two herbal substances, on telomerase gene expression in breast cancer cells."
Our news editors obtained a quote from the research from the Tabriz University of Medical Sciences, "For determination of cell viability tetrazolium-based assays were conducted after 24, 48, and 72 h exposure times and expression of human telomerase reverse transcriptase gene was measured with real-time PCR. Each compound exerted cytotoxic effects on T47D cells and inhibited telomerase gene expression, both in a time-and dose-dependent manner. The mixture of curcumin and silibinin showed relatively more inhibitory effect on growth of T47D cells and hTERT gene expression as compared with either agent alone."
According to the news editors, the research concluded: "These findings suggest that cell viability along with hTERT gene expression in breast cancer cells could be reduced by curcumin and silibinin."
For more information on this research see: Curcumin and silibinin inhibit telomerase expression in T47D human breast cancer cells. Asian Pacific Journal of Cancer Prevention, 2013;14(6):3449-53 (see also technology.html">Biotechnology).
The news editors report that additional information may be obtained by contacting M. Nasiri, Dept. of Medical Biotechnology, Faculty of Advanced Medical Sciences, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Additional authors for this research include N. Zarghami, K.N. Koshki, M. Mollazadeh, M.P. Moghaddam, M.R. Yamchi, R.J. Esfahlan, A. Barkhordari and A. Alibakhshi.
Keywords for this news article include: Iran, Asia, Biotechnology, Tabriz, Alkanes, Curcumin, Oncology, Catechols, Telomerase, Hydrocarbons, Breast Cancer, Women's Health, Carrier Proteins, Diarylheptanoids, Organic Chemicals, Ribonucleoproteins, Cancer Gene Therapy, Phosphotransferases, DNA Nucleotidyltransferases, RNA Directed DNA Polymerase.
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