By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Enzymes and Coenzymes have been published. According to news reporting from Bangkok, Thailand, by NewsRx journalists, research stated, "In this work, a highly sensitive enzyme-based biosensor is developed based on graphene-poly(3,4-ethylenedioxythiophene):polystyrene sulfonic acid (GP-PEDOT:PSS) modified screen printed carbon electrode (SPCE) for electrochemical detection of glucose. GP-PEDOT:PSS nanocomposite synthesized by one-step electrolytic exfoliation is drop-coated on SPCE and glucose oxidase (GOD) enzyme is then immobilized on GP-PEDOT:PSS by glutaraldehyde cross linking."
The news correspondents obtained a quote from the research from Mahidol University, "Electron microscope characterization confirms the presence of multi-layer graphene sheets and the appearance of smooth and long microstripe structure of GOD on the electrode surface. Direct electrochemistry of GOD at the GP/PEDOT:PSS electrode is observed by cyclic voltammetry and graphene plays the main role in a quasi-reversible redox process. GOD/GP-PEDOT:PSS electrode exhibits a high amperometric sensitivity of 7.23 mu A/mM, which is about 13 times higher than that of GOD/PEDOT:PSS but has a relatively narrow linear dynamic range of similar to 20-900 mu M. Moreover, GOD/GP-PEDOT:PSS offers a very low detection limits (3S/N) of similar to 0.3 mu M which is better or comparable to other recent reports of highly sensitive glucose biosensors."
According to the news reporters, the research concluded: "Furthermore, the sensor has good stability with only 30% loss of enzyme activity after 30 days."
For more information on this research see: Graphene-PEDOT:PSS on screen printed carbon electrode for enzymatic biosensing. Journal of Electroanalytical Chemistry, 2013;704():208-213. Journal of Electroanalytical Chemistry can be contacted at: Elsevier Science Sa, PO Box 564, 1001 Lausanne, Switzerland (see also Enzymes and Coenzymes).
Our news journalists report that additional information may be obtained by contacting A. Wisitsoraat, Mahidol University, Bangkok 10700, Thailand. Additional authors for this research include S. Pakapongpan, C. Sriprachuabwong, D. Phokharatkul, P. Sritongkham, T. Lomas and A. Tuantranont.
Keywords for this news article include: Asia, Bangkok, Thailand, Enzymes and Coenzymes
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