By a News Reporter-Staff News Editor at Clinical Trials Week -- New research on Diabetes is the subject of a report. According to news reporting originating from Chicago, Illinois, by NewsRx correspondents, research stated, "To investigate the effect of panretinal photocoagulation (PRP) on retinal blood flow and shear rate using Doppler Fourier-domain optical coherence tomography (FD-OCT) in poorly controlled diabetics with proliferative diabetic retinopathy (PDR). This was a prospective interventional pilot study in patients with a new clinical diagnosis of PDR."
Our news editors obtained a quote from the research from Northwestern University, "Retinal blood flow and vessel diameter were measured using Doppler FD-OCT according to a previously described method, immediately before PRP treatment and 7 to 8 weeks after the last PRP session. Ten patients with poorly controlled PDR (mean hemoglobin A1C = 9.2 +/- 2.0%) and 10 control subjects were included in the study. PDR patients had significantly lower blood flow (similar to 25%) than control subjects both at baseline (P = 0.01) and after PRP (P = 0.003). Compared to controls, venous and arterial velocities were significantly decreased in diabetics at baseline (similar to 27%; P< 0.001 and 0.017, respectively) as well as after PRP (P < 0.001 and 0.006, respectively). Compared to controls, venous and arterial shear rates were significantly reduced in diabetics at baseline (similar to 27%; P = 0.002, 0.03) and after PRP (P = 0.002, 0.03). PRP in this group of PDR patients did not have a statistically significant effect on retinal blood flow or vessel parameters, though there was a trend for decreased arterial diameter (P = 0.09). This is the first study to use Doppler FD-OCT to quantify functional changes in retinal vascular parameters in poorly controlled PDR patients."
According to the news editors, the research concluded: "Compared to controls, blood flow parameters in these patients were decreased at baseline, but did not decrease further following PRP, with important implications related to diabetes control, endothelial function, and therapeutic response."
For more information on this research see: Pilot Study of Doppler Optical Coherence Tomography of Retinal Blood Flow Following Laser Photocoagulation in Poorly Controlled Diabetic Patients. Investigative Ophthalmology & Visual Science, 2013;54(9):6104-6111. Investigative Ophthalmology & Visual Science can be contacted at: Assoc Research Vision Ophthalmology Inc, 12300 Twinbrook Parkway, Rockville, MD 20852-1606, USA. (The Association for Research in Vision and Ophthalmology - www.arvo.org; Investigative Ophthalmology & Visual Science - www.iovs.org/)
The news editors report that additional information may be obtained by contacting J.C. Lee, Northwestern University, Dept. of Ophthalmol, Feinberg Sch Med, Chicago, IL 60611, United States. Additional authors for this research include B.J. Wong, O. Tan, S. Srinivas, S.R. Sadda, D. Huang and A.A. Fawzi (see also Diabetes).
Keywords for this news article include: Biotechnology, Biomedical, Chicago, Illinois, Diabetes, United States, Endocrinology, Photocoagulation, Imaging Technology, North and Central America, Clinical Trials and Studies, Optical Coherence Tomography
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