Computed FFRCT Identifies Flow-Restricting Arterial
Blockages with High Accuracy
The study’s findings were presented today in a First Report Investigation session at the 25th Annual Transcatheter Cardiovascular Therapeutics (TCT) meeting in
HeartFlow’s patient-specific coronary blood flow modeling technology is a new non-invasive test that uses proprietary algorithms based on computational fluid dynamics and data from a patient’s coronary CT scan to assist physicians in the diagnosis of coronary artery disease and identification of specific flow-restricting blockages in the coronary arteries.
The prospective international HeartFlowNXT study enrolled 254 stable patients with suspected coronary artery disease (CAD) at 10 centers in seven countries. The objective of the study was to compare diagnostic performance of FFRCT, coronary CT, and ICA, to invasive FFR measurement (the current gold standard for determining flow-restricting arterial blockages). All patients underwent coronary CT, invasive coronary angiography (ICA), and invasive FFR, and then had FFRCT analysis performed using the latest generation of HeartFlow’s software technology.
The findings of the study suggest the potential to eliminate the need for risky and expensive invasive evaluation and treatment in some patients. FFRCT demonstrated superior ability to correctly identify those patients without coronary ischemia compared to coronary CT (specificity 79% vs. 34%). The study also showed a specificity of 79% compared to invasive angiography of 51%. FFRCT correctly identified patients who had coronary ischemia with a high sensitivity (86%) and high negative predictive value (92%). There was also a striking improvement in the ability of FFRCT to discriminate patients with and without flow-restricting arterial blockages compared to CT alone (area under the curve [AUC] on receiver operating characteristics analysis 0.82 vs. 0.63, p<0.0001). AUC is a robust measure of diagnostic test reliability and accuracy.
“Proper selection of patients for invasive diagnosis and treatment is a crucial element of taking care of people who may have coronary artery disease. These procedures entail risk and expense. This new tool will be an exciting step forward for cardiology and may significantly improve how we guide coronary artery disease patients towards effective and efficient care,” said principal investigator