By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on Cardiovascular Diseases is the subject of a report. According to news originating from Albany, New York, by NewsRx correspondents, research stated, "Orai proteins form highly calcium (Ca(2+))-selective channels located in the plasma membrane of both nonexcitable and excitable cells, where they make important contributions to many cellular processes. The well-characterized Ca(2+) release-activated Ca(2+) current is mediated by Orai1 multimers and is activated, upon depletion of inositol 1,4,5-trisphosphate-sensitive stores, by direct interaction of Orai1 with the endoplasmic reticulum Ca(2+) sensor, stromal interaction molecule 1 (STIM1)."
Our news journalists obtained a quote from the research from the State University of New York, "This pathway is known as capacitative Ca(2+) entry or store-operated Ca(2+) entry. While most investigations have focused on STIM1 and Orai1 in their store-dependent mode, emerging evidence suggests that Orai1 and Orai3 heteromultimeric channels can form store-independent Ca(2+)-selective channels. The role of store-dependent and store-independent channels in excitation-transcription coupling and the pathological remodeling of the cardiovascular system are beginning to come forth. Recent evidence suggests that STIM/Orai-generated Ca(2+) signaling couples to gene transcription and subsequent phenotypic changes associated with the processes of cardiac and vascular remodeling."
According to the news editors, the research concluded: "This short review will explore the contributions of native Orai channels to heart and vessel physiology and their role in cardiovascular diseases."
For more information on this research see: Emerging roles for native Orai Ca2+ channels in cardiovascular disease. Current Topics In Membranes, 2013;71():209-35 (see also Cardiovascular Diseases).
The news correspondents report that additional information may be obtained from B. Ruhle, Nanobioscience Constellation, The College of Nanoscale Science and Engineering, University at Albany-State University of New York, Albany, NY, United States.
Keywords for this news article include: Albany, New York, Cardiology, United States, Cardiovascular Diseases, North and Central America.
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