By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- A new study on Biotechnology is now available. According to news reporting originating in Suzhou, People's Republic of China, by NewsRx journalists, research stated, "Understanding how nanovectors transport DNA molecules through cell membranes is of great importance in gene therapy. In this paper, we systematically investigate the mechanism of cellular uptake of cationic polymeric nanovectors containing DNA molecules through dissipative particle dynamics simulations."
The news reporters obtained a quote from the research from Soochow University, "Our results show that the property of polyelectrolyte chains grafted to nanovector and DNA molecules can have important impacts on the endocytosis. Interestingly, it is found that the nanovector can be fully taken up with proper number of DNA molecules on its surface. On the contrary, in the absence of DNA it may become harder to be totally engulfed. Since the adsorption number of DNA is related to external pH, the cellular uptake could exhibit pH-responsive behavior. Further, we also provide insights into the comparison of uptake behaviors between cancer and normal cells, and importantly, we find that the enhanced uptake of gene nanovectors may be an inherent property of cancer cells."
According to the news reporters, the research concluded: "The present study may give some significant suggestions on future nanovector design for gene delivery."
For more information on this research see: Design maps for cellular uptake of gene nanovectors by computer simulation. Biomaterials, 2013;34(33):8401-8407. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news correspondents report that additional information may be obtained by contacting H.M. Ding, Soochow Univ, Center Soft Condensed Matter Phys & Interdisciplinar, Suzhou 215006, People's Republic of China (see also technology.html">Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Suzhou, Computers, Nanovectors, DNA Research, Bioengineering, Nanotechnology, Cancer Gene Therapy, Emerging Technologies, People's Republic of China
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