By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Researchers detail new data in Biotechnology. According to news reporting originating from Moscow, Russia, by NewsRx correspondents, research stated, "One effective method for the prevention and treatment of influenza infection is passive immunization. In our study, we examined the feasibility of creating an antibody-based preparation with a prolonged protective effect against influenza virus."
Our news editors obtained a quote from the research from Institute for Epidemiology and Microbiology, "Single-domain antibodies (sdAbs) specific for influenza virus hemagglutinin were generated. Experiments in mouse models showed 100% survivability for both intranasal sdAbs administration 24h prior to influenza challenge and 24h after infection. sdAb-gene delivery by an adenoviral vector led to gene expression for up to 14days. Protection by a recombinant adenovirus containing the sdAb gene was observed in cases of administration prior to influenza infection (14d-24h). We also demonstrated that the single administration of a combined preparation containing sdAb DNA and protein expanded the protection time window from 14d prior to 48h after influenza infection."
According to the news editors, the research concluded: "This approach and the application of a broad-spectrum sdAbs will allow the development of efficient drugs for the prevention and treatment of viral infections produced by pandemic virus variants and other infections."
For more information on this research see: Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection. Antiviral Research, 2013;97(3):318-28. (Elsevier - www.elsevier.com; Antiviral Research - www.elsevier.com/wps/product/cws_home/521852)
The news editors report that additional information may be obtained by contacting I.L. Tutykhina, Gamaleya Research Institute for Epidemiology and Microbiology, 18, Gamaleya Street, Moscow 123098, Russia. Additional authors for this research include E.S. Sedova, I.Y. Gribova, T.I. Ivanova, L.A. Vasilev, M.V. Rutovskaya, A.A. Lysenko, M.M. Shmarov, D.Y. Logunov, B.S. Naroditsky, S.V. Tillib and A.L Gintsburg (see also technology.html">Biotechnology).
Keywords for this news article include: Antibodies, Biotechnology, Moscow, Russia, Eurasia, Viruses, Virology, Treatment, Adenovirus, Immunology, Gene Therapy, Bioengineering, Blood Proteins, Viral Vaccines, Immunoglobulins, Influenza Vaccines.
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