By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Proteins have been published. According to news reporting originating in Clemson, South Carolina, by NewsRx journalists, research stated, "Fibrin fibers form the structural scaffold of blood clots. Thus, their mechanical properties are of central importance to understanding hemostasis and thrombotic disease."
The news reporters obtained a quote from the research from Clemson University, "Recent studies have revealed that fibrin fibers are elastomeric despite their high degree of molecular ordering. These results have inspired a variety of molecular models for fibrin's elasticity, ranging from reversible protein unfolding to rubber-like elasticity. An important property that has not been explored is the timescale of elastic recoil, a parameter that is critical for fibrin's mechanical function and places a temporal constraint on molecular models of fiber elasticity. Using high-frame-rate imaging and atomic force microscopy-based nanomanipulation, we measured the recoil dynamics of individual fibrin fibers and found that the recoil was orders of magnitude faster than anticipated from models involving protein refolding. We also performed steered discrete molecular-dynamics simulations to investigate the molecular origins of the observed recoil."
According to the news reporters, the research concluded: "Our results point to the unstructured alpha C regions of the otherwise structured fibrin molecule as being responsible for the elastic recoil of the fibers."
For more information on this research see: Submillisecond Elastic Recoil Reveals Molecular Origins of Fibrin Fiber Mechanics. Biophysical Journal, 2013;104(12):2671-2680. Biophysical Journal can be contacted at: Cell Press, 600 Technology Square, 5TH Floor, Cambridge, MA 02139, USA. (Elsevier - www.elsevier.com; Biophysical Journal - www.elsevier.com/wps/product/cws_home/716950)
Our news correspondents report that additional information may be obtained by contacting N.E. Hudson, Clemson University, Dept. of Phys & Astron, Clemson, SC 29634, United States. Additional authors for this research include F. Ding, I. Bucay, E.T. O'Brien, O.V. Gorkun, R. Superfine, S.T. Lord, N.V. Dokholyan and M.R. Falvo (see also Proteins).
Keywords for this news article include: Fibrin, Clemson, United States, South Carolina, Blood Proteins, North and Central America
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