By a News Reporter-Staff News Editor at Science Letter -- A new study on Essential Amino Acids is now available. According to news reporting originating in Beirut, Lebanon, by NewsRx journalists, research stated, "We introduce a novel method for encapsulation of curcumin by synthesizing microcapsule containing self-assembled nanoparticles using poly (L-lysine), trisodium citrate and silica sol. Such microcapsules can only be prepared in neutral and alkaline environment and unencapsulated curcumin can be effectively removed by simple centrifugation with encapsulation efficiency 57.34%."
The news reporters obtained a quote from the research from American University, "The particle sizes are in the range 0.7-3 mu m with an effective diameter 1.05 mu m. The structure of the microcapsules is dependent upon the solubility of curcumin in the solvent environment, the microcapsule are spherical when prepared in 10% acetone and bowl-shaped/conical when prepared in water suspension, however, the size of these curcumin encapsulated microcapsules remain similar. Fluorescence microscope images confirm that curcumin is predominantly concentrated within the shell wall of the capsules. Photophysical behavior of Micro-curcumin with respect to curcumin alone is evaluated. Release of curcumin is found to be triggered by pH where acidic environment trigger maximum release compared to basic and neutral conditions. Micro-curcumin is as stable as curcumin. Drug release efficiency is found to be 61.44% and the drug release profile of Micro-curcumin follow Higuchi model. It is also revealed that beta-diketone group of curcumin responsible for scavenging activity is retained in the Micro-curcumin, thus suggesting applicability of such system as a poorly water soluble drug delivery vehicle. In contrast to other curcumin delivery systems, the presented method is easy, fast and does not need flow rate monitoring device."
According to the news reporters, the research concluded: "In addition poly (L-lysine) as a non-toxic and highly stable material that prevents metabolic degradation is used in the present preparation method."
For more information on this research see: A new method for pH triggered curcumin release by applying poly(L-lysine) mediated nanoparticle-congregation. Analytica Chimica Acta, 2013;795():60-68. Analytica Chimica Acta can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Analytica Chimica Acta - www.elsevier.com/wps/product/cws_home/502681)
Our news correspondents report that additional information may be obtained by contacting D. Patra, American University of Beirut, Fac Arts & Sci, Dept. of Chem, Beirut 11072020, Lebanon (see also Essential Amino Acids).
Keywords for this news article include: Asia, Beirut, Lysine, Lebanon, Basic Amino Acids, Diamino Amino Acids, Essential Amino Acids
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