Study published in Translational Oncology highlights growing interest in non-invasive oncology diagnostics
A key finding of the study, published in Translational Oncology, shows that the IsoFlux System recovers enough CTCs for mutational profiling in a majority of patients tested (87% for colorectal and 95% for prostate cancer). For colorectal patients, 50% displayed a CTC-based KRAS mutation, a level that is in line with tissue-based mutational profiling of this indication. The high sensitivity of the IsoFlux system was also demonstrated by comparing CTC recovery from matched prostate patient samples as compared to other leading instruments. The percent of patients with five or more CTCs per 7mL blood draw was 95% with IsoFlux, compared to 36% with CellSearch.
“The ability to track clinically relevant biomarkers longitudinally is one of the primary advantages of CTCs,” said
Customers have adopted the IsoFlux System to isolate and characterize CTCs for biomarkers including gene expression, mutations (qPCR and next generation sequencing), and chromosomal aberrations. More information can be found at www.fluxionbio.com/IsoFlux.
About Fluxion Biosciences
Fluxion Biosciences provides cellular analysis tools for use in critical life science, drug discovery, and diagnostic applications. Products include the BioFlux™ System for studying cellular interactions, the IonFlux™ System for high throughput patch clamp measurements, and the IsoFlux™ System for circulating tumor cells. Fluxion’s systems are designed to replace laborious and difficult assays by providing intuitive, easy-to-use instruments for cell-based analysis. For more information about Fluxion Biosciences, visit www.fluxionbio.com.
Source: Fluxion Biosciences
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