A hands-free ultrasound device combined with a clot-busting drug was safe for ischemic stroke (http://www.strokeassociation.org/STROKEORG/AboutStroke/TypesofStroke/IschemicClots/Ischemic-Strokes-Clots_UCM_310939_Article.jsp)patients in a phase II pilot study, reported in the
The device is placed on the stroke patient's head and delivers ultrasound to enhance the effectiveness of the clot-busting drug tissue plasminogen activator (tPA).( http://strokeassociation.org/STROKEORG/AboutStroke/Treatment/Stroke-Treatments_UCM_310892_Article.jsp)
Unlike the traditional hand-held ultrasound probe that's aimed at a blood clot, the hands-free device used 18 separate probes and showers the deep areas of the brain where large blood clots cause severe strokes.
"Our goal is to open up more arteries in the brain and help stroke patients recover," said
In the first-in-human study, 20 moderately severe ischemic stroke patients (12 men and 8 women, average age 63 years) received intravenous tPA up to 4.5 hours after symptoms occurred and two hours exposure to 2-MHz pulsed wave transcranial ultrasound.
Researchers reported that 13 (or 65 percent) patients either returned home or to rehabilitation 90 days after the combination treatment.
After three months, five of the 20 patients had no disability from the stroke and one had slight disability.
Researchers have launched an 830-patient international, randomized efficacy study of the ultrasound approach combined with the clot buster in ischemic stroke.
The study was conducted at the
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