Thioredoxins (Trxs) are small proteins present in most living organisms. In the course of her research
Human albumin is the most widely used intravenous protein in the world for therapeutic purposes. It is used to stabilize blood volume and prevent the risk of infarction, and its application in operating theatres is almost a daily occurrence. It is also used in burns, surgical operations, haemorrhages, or when the patient is undernourished or dehydrated, and in the case of chronic infections and renal or hepatic diseases.
Although commercial albumin is extracted from blood, the lack of a sufficient volume in reserve has prompted many researchers to seek new formulas for obtaining this protein on a large scale economically and safely. "We have come up with an easier, cheaper procedure for producing it in the tobacco plant and extracting it. By fusing the genes encoding the Trxs f or m, we increased the amount of recombinant protein (the albumin, in this case). We also managed to improve the solubility and folding of the albumin, which helps to extract it from the plant and lowers the costs involved in this process."
Tobacco for producing bioethanol
As the research progressed, thioredoxin f was shown for the first time in vivo to be more efficient than Trx m in regulating the metabolism of carbohydrates, as it causes "a significant increase in the amount of starch in the leaves, which can reach 700% with respect to the amount obtained from non-modified control plants."
Once the regulating function of Trx f in starch synthesis had been proven, the researcher focussed on its possible application in energy crops used to produce bioethanol: "We saw that the leaves of the genetically modified tobacco plants were releasing 500% more fermentable sugars. With these sugars, which could later be turned into bioethanol, one could obtain up to 40 litres of bioethanol per tonne of fresh leaves -according to the theoretical calculation provided by the
Genetically enhanced tobacco could be an alternative source of biomass in areas like Extremadura and Andalusia, the traditional tobacco producers. The estimated calculations of the starch production of these enhanced varieties would be the equivalent to those of crops like barley or wheat. "As cereals are currently being used as the raw material to produce bioethanol, genetically enhanced tobacco could be an alternative source of biomass and for obtaining clean energies."
Keywords for this news article include: Biotechnology, Energy, Biofuel, Amino Acids, Oil and Gas, Thioredoxins, Bioengineering, Elhuyar Fundazioa, Peptides and Proteins.
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