By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Nanoparticles. According to news originating from Penang, Malaysia, by NewsRx correspondents, research stated, "The development of mesoporous silica nanoparticle-based platforms for a controlled drug delivery was studied. Mesoporous silica nanoparticles (MSN) was synthesized and modified with 3-aminopropyltriethoxysilane (APTES) using co-condensation (MSNco) and post-grafting (MSNEpost) methods."
Our news journalists obtained a quote from the research from the University of Science Malaysia, "X-ray diffraction (XRD) and transmission electron microscopy (TEM) data confirmed the formation of ordered mesostructured silica nanoparticles. The performance of MSNs was then tested on an ibuprofen immobilization and release. The results revealed that unmodified MSN demonstrated the best immobilization rate and capacity of ibuprofen (98%), MSNpost exhibited higher ibuprofen adsorption (78%) as compared to MSNco. (71%), suggesting the modification method is not the dominant factor for the adsorption studied. In fact, according to the FT-IR results, the silanol groups density was found to be the contributing factor that affected the adsorption. The in vitro drug release was also investigated with simulated biological fluids. In 20 h, MSNco showed the fastest release of ibuprofen (100%), followed by MSN (50%) and MSNpost (38%). Both pore size and amine groups influenced the rate of the release process. From the results, MSN and MSNpost is suggested to have suitable features for slow drug release which provides constant release over a defined period to avoid repeated administration."
According to the news editors, the research concluded: "While MSN, could be best employed as a fast release system that provides initial burst of drug release to achieve rapid and maximum relief."
For more information on this research see: Role of 3-aminopropyltriethoxysilane in the preparation of mesoporous silica nanoparticles for ibuprofen delivery: Effect on physicochemical properties. Microporous and Mesoporous Materials, 2013;180():235-241. Microporous and Mesoporous Materials can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Microporous and Mesoporous Materials - www.elsevier.com/wps/product/cws_home/600760)
The news correspondents report that additional information may be obtained from N.H.N. Kamarudin, University of Sains Malaysia, Sch Chem Engn, Nibong Tebal 14300, Penang, Malaysia. Additional authors for this research include A.A. Jalil, S. Triwahyono, N.F.M. Salleh, A.H. Karim, R.R. Mukti, B.H. Hameed and A. Ahmad (see also Nanoparticles).
Keywords for this news article include: Asia, Penang, Malaysia, Nanotechnology, Silicon Nanocrystals, Emerging Technologies
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