By a News Reporter-Staff News Editor at Science Letter -- Investigators publish new report on Nanoparticles. According to news reporting originating in Stanford, California, by NewsRx journalists, research stated, "The use of nanoparticles for the diagnosis and treatment of cancer requires the complete characterization of their toxicity, including accurately locating them within biological tissues. Owing to their size, traditional light microscopy techniques are unable to resolve them."
The news reporters obtained a quote from the research from Stanford University, "Transmission electron microscopy provides the necessary spatial resolution to image individual nanoparticles in tissue, but is severely limited by the very small analysis volume, usually on the order of tens of cubic microns. In this work, we developed a scanning transmission electron microscopy (STEM) approach to analyze large volumes of tissue for the presence of polyethylene glycol-coated Raman-active-silica-gold-nanoparticles (PEG-R-Si-Au-NPs). This approach utilizes the simultaneous bright and dark field imaging capabilities of STEM along with careful control of the image contrast settings to readily identify PEG-R-Si-Au-NPs in mouse liver tissue without the need for additional time-consuming analytical characterization. We utilized this technique to analyze 243,000 mu m(3) of mouse liver tissue for the presence of PEG-R-Si-Au-NPs."
According to the news reporters, the research concluded: "Nanoparticles injected into the mice intravenously via the tail vein accumulated in the liver, whereas those injected intrarectally did not, indicating that they remain in the colon and do not pass through the colon wall into the systemic circulation."
For more information on this research see: A Scanning Transmission Electron Microscopy Approach to Analyzing Large Volumes of Tissue to Detect Nanoparticles. Microscopy and Microanalysis, 2013;19(5):1290-1297. Microscopy and Microanalysis can be contacted at: Cambridge Univ Press, 32 Avenue Of The Americas, New York, NY 10013-2473, USA. (Cambridge University Press - www.cambridge.org; Microscopy and Microanalysis - journals.cambridge.org/action/displayJournal?jid=MAM)
Our news correspondents report that additional information may be obtained by contacting P.J. Kempen, Stanford University, Bio X Program, Stanford, CA 94305, United States. Additional authors for this research include A.S. Thakor, C. Zavaleta, S.S. Gambhir and R. Sinclair (see also Nanoparticles).
Keywords for this news article include: Stanford, California, United States, Nanotechnology, Emerging Technologies, North and Central America
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