Researchers in the
Knee injuries account for more than 25 percent of all orthopedic treatments in the U.S., and more than half of all sports injuries. One of the most common knee injuries is a torn anterior cruciate ligament (ACL), which is typically repaired surgically using tissue grafts. However, ACL repair results in a high rate of repeat surgeries, due to the lack of regrowth of soft tissue in the knee.
"Although numerous replacements for injured soft tissue structures have been developed, they typically fail to address the soft-tissue-to-bone interface," Popat explained. "This interface is necessary for the proper function of the entire joint."
"The strategy is to recapitulate different aspects of the development process, where all tissues are derived from soft tissue precursors and specific environmental cues," Donahue said. "This approach is innovative in providing engineered tissue grafts with the capacity to promote the formation of a gradient from soft to hard tissue."
The interdisciplinary project incorporates materials research, engineering, cell biology, and biomaterials. Much of the research at
Results of the research are expected to be published starting in 2014.
TNS 30TagarumaMar-131024-4526512 30TagarumaMar
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