By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Molecular Biology is the subject of a report. According to news originating from Talca, Chile, by NewsRx correspondents, research stated, "In the past 30 years, only three natural products have been sources of new drugs with antiplatelet activity. In this study, we have demonstrated for the first time that guanosine from Solanum lycopersicum possesses antiplatelet (secretion, spreading, adhesion and aggregation) activity in vitro and inhibition of platelet inflammatory mediator of atherosclerosis (sCD40L)."
Our news journalists obtained a quote from the research from the University of Talca, "According to ADP-induced platelet aggregation inhibiting, the total extract residue was fractionated by liquid chromatography/phase separation, affording an aqueous fraction. This fraction was subjected to repeated permeation over Sephadex LH-20 and semi-preparative TLC. The isolated compound finally obtained was identified as guanosine on the basis of its UV-spectra, HPLC and 1H-NMR data. Guanosine concentration dose-dependently (1 to 4 mmol/L) inhibited platelet secretion and aggregation induced by ADP and collagen. Spread of human platelets on collagen in the presence of guanosine was fully inhibited. After incubation of whole blood with guanosine, the platelet adhesion and aggregation under flow conditions was inhibited concentration dependently (0.2 to 2 mmol/L). At the same concentrations that guanosine inhibits platelet aggregation, levels of sCD40L were significantly decreased."
According to the news editors, the research concluded: "Guanosine is thus likely to exert significant protective effects in thromboembolic-related disorders by inhibiting platelet aggregation."
For more information on this research see: Protective mechanisms of guanosine from Solanum lycopersicum on agonist-induced platelet activation: role of sCD40L. Molecules, 2013;18(7):8120-35. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)
The news correspondents report that additional information may be obtained from E. Fuentes, Dept. of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca 3460000, Chile. Additional authors for this research include M. Alarcon, L. Astudillo, C. Valenzuela, M. Gutierrez and I. Palomo (see also Molecular Biology).
Keywords for this news article include: Talca, Chile, South America, Molecular Biology.
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