By a News Reporter-Staff News Editor at Gastroenterology Week -- Current study results on Adenocarcinomas have been published. According to news reporting originating from Tucson, Arizona, by NewsRx correspondents, research stated, "Early detection of pancreatic ductal adenocarcinoma (PDAC) allows for surgical resection and increases patient survival times. Imaging agents that bind and amplify the signal of neovascular proteins in neoplasms can be detected by ultrasound, enabling accurate detection of small lesions."
Our news editors obtained a quote from the research from Ventana Medical Systems Inc, "We searched for new markers of neovasculature in PDAC and assessed their potential for tumor detection by ultrasound molecular imaging. Thymocyte differentiation antigen 1 (Thy1) was identified as a specific biomarker of PDAC neovasculature by proteomic analysis. Up-regulation in PDAC was validated by immunohistochemical analysis of pancreatic tissue samples from 28 healthy individuals, 15 with primary chronic pancreatitis tissues, and 196 with PDAC. Binding of Thy1-targeted contrast microbubbles was assessed in cultured cells, in mice with orthotopic PDAC xenograft tumors expressing human Thy1 on the neovasculature, and on the neovasculature of a genetic mouse model of PDAC. Based on immunohistochemical analyses, levels of Thy1 were significantly higher in the vascular of human PDAC than chronic pancreatitis (P = .007) or normal tissue samples (P < .0001). In mice, ultrasound imaging accurately detected human Thy1-positive PDAC xenografts, as well as PDACs that express endogenous Thy1 in genetic mouse models of PDAC. We have identified and validated Thy1 as a marker of PDAC that can be detected by ultrasound molecular imaging in mice."
According to the news editors, the research concluded: "The development of a specific imaging agent and identification of Thy1 as a new biomarker could aid in the diagnosis of this cancer and management of patients."
For more information on this research see: Detection of Pancreatic Ductal Adenocarcinoma in Mice by Ultrasound Imaging of Thymocyte Differentiation Antigen 1. Gastroenterology, 2013;145(4):885-894,290-292. Gastroenterology can be contacted at: W B Saunders Co-Elsevier Inc, 1600 John F Kennedy Boulevard, Ste 1800, Philadelphia, PA 19103-2899, USA. (Elsevier - www.elsevier.com; Gastroenterology - www.elsevier.com/wps/product/cws_home/623297)
The news editors report that additional information may be obtained by contacting K. Foygel, Ventana Med Syst Inc, Translat Diagnost, Tucson, AZ, United States. Additional authors for this research include H.J. Wang, S. Machtaler, A.M. Lutz, R. Chen, M. Pysz, A.W. Lowe, L. Tian, T. Carrigan, T.A. Brentnall and J.K. Willmann (see also Adenocarcinomas).
Keywords for this news article include: Tucson, Arizona, Genetics, Pancreas, Immunology, United States, Nanotechnology, Adenocarcinomas, Gastroenterology, Surface Antigens, Molecular Imaging, Biological Markers, Emerging Technologies, Differentiation Antigens, North and Central America
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