By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Molecular Recognition. According to news reporting originating in Beijing, People's Republic of China, by NewsRx journalists, research stated, "Gibberellin (GA) is an essential plant hormone and plays a significant role during the growth and development of the higher plants. The molecular recognition mode between GA and receptor Arabidopsis thaliana GIBBERELLIN INSENSITIVE DWARF1 A (AtGID1A) was investigated by molecular docking and dynamics simulations to clarify the selective perceived mechanism of different bioactive GA molecules to AtGID1A."
The news reporters obtained a quote from the research from the College of Chemistry and Chemical Engineering, "The 6-COOH group of GA, especially its beta configuration, was found to be an indispensable pharmacophore group for GA recognition and binding to AtGID1A. Not only does a strong salt bridge interaction between the 6 beta-COOH group of GA and Arg244 of AtGID1A play a very important role in the GA recognition of the receptor, but also an indirect water bridge interaction between the pharmacophore group 6 beta-COOH of GA and the residue Tyr322 of AtGID1A is essential for the GA binding to the receptor. The site-directed residues mutant modeling study on the receptor-binding pocket confirmed that the mutations of Arg244 and Tyr322 decreased the GA binding activity due to the disappearances of the salt bridge and the hydrogen bond interaction. The 3 beta-OH group of GA was well known to be necessary for the GA bioactivity due to its forming a unique hydrogen bond with Tyr127 of AtGID1A. In addition, the hydrophobic interaction between GA and AtGID1A was considered a necessary factor to lock the GA active conformation and stabilize the GA-GID1A complex structure."
According to the news reporters, the research concluded: "The novel molecular recognition mode will be beneficial in elucidating the GA regulation function on the growth and development of the higher plants."
For more information on this research see: Computational insight into novel molecular recognition mechanism of different bioactive GAs and the Arabidopsis receptor GID1A. Journal of Molecular Modeling, 2013;19(10):4613-4624. Journal of Molecular Modeling can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Journal of Molecular Modeling - www.springerlink.com/content/1610-2940/)
Our news correspondents report that additional information may be obtained by contacting H.X. Duan, Chinese Academy Sci, Coll Chem & Chem Engn, Grad Univ, Beijing 100049, People's Republic of China. Additional authors for this research include D.L. Li, H.C. Liu, D.S. Liang and X.L. Yang (see also Molecular Recognition).
Keywords for this news article include: Asia, Beijing, Nanotechnology, Emerging Technologies, Molecular Recognition, People's Republic of China
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