By a News Reporter-Staff News Editor at Biotech Business Week -- Research findings on Nanoparticles are discussed in a new report. According to news reporting originating from Exeter, United Kingdom, by NewsRx correspondents, research stated, "Silver nanoparticles cause toxicity in exposed organisms and are an environmental health concern. The mechanisms of silver nanoparticle toxicity, however, remain unclear."
Our news editors obtained a quote from the research from the University of Exeter, "We examined the effects of exposure to silver in nano-, bulk-, and ionic forms on zebrafish embryos (Danio rerio) using a Next Generation Sequencing approach in an Illumina platform (High-Throughput SuperSAGE). Significant alterations in gene expression were found for all treatments and many of the gene pathways affected, most notably those associated with oxidative phosphorylation and protein synthesis, overlapped strongly between the three treatments indicating similar mechanisms of toxicity for the three forms of silver studied. Changes in oxidative phosphorylation indicated a down-regulation of this pathway at 24 h of exposure, but with a recovery at 48 h. This finding was consistent with a dose-dependent decrease in oxygen consumption at 24 h, but not at 48 h, following exposure to silver ions. Overall, our data provide support for the hypothesis that the toxicity caused by silver nanoparticles is principally associated with bioavailable silver ions in exposed zebrafish embryos."
According to the news editors, the research concluded: "These findings are important in the evaluation of the risk that silver particles may pose to exposed vertebrate organisms."
For more information on this research see: Molecular mechanisms of toxicity of silver nanoparticles in zebrafish embryos. Environmental Science & Technology, 2013;47(14):8005-14. (American Chemical Society - www.acs.org; Environmental Science & Technology - www.pubs.acs.org/journal/esthag)
The news editors report that additional information may be obtained by contacting R. van Aerle, Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, UK. Additional authors for this research include A. Lange, A. Moorhouse, K. Paszkiewicz, K. Ball, B.D. Johnston, E. de-Bastos, T. Booth, C.R. Tyler and E.M Santos (see also Nanoparticles).
Keywords for this news article include: Exeter, Europe, United Kingdom, Nanotechnology, Emerging Technologies.
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