By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Brain Research. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "The blood-brain barrier (BBB) restricts the delivery of many potentially important therapeutic agents for the treatment of brain disorders. An efficient strategy for brain targeted delivery is the utilization of the targeting ligand conjugated nanoparticles to trigger the receptor-mediated transcytosis."
Our news journalists obtained a quote from the research from Capital Medical University, "In this study, transferrin (Tf) was employed as a brain targeting ligand to functionalize the fluorescein-loaded magnetic nanoparticles (FMNs). The Tf conjugated FMNs (Tf-FMNs) were characterized by transmission electron microscopy, thermal gravimetric analysis, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. Using fluorescein as an optical probe, the potential of Tf-FMNs as brain targeting drug carriers was explored in vivo. It was demonstrated that Tf-FMNs were able to cross the intact BBB, diffuse into brain neurons, and distribute in the cytoplasm, dendrites, axons, and synapses of neurons. In contrast, magnetic nanoparticles without Tf conjugation cannot cross the BBB efficiently under the same conditions."
According to the news editors, the research concluded: "Therefore, Tf-FMNs hold great potential in serving as an efficient multifunctional platform for the brain-targeted theranostics."
For more information on this research see: Transferrin-conjugated, fluorescein-loaded magnetic nanoparticles for targeted delivery across the blood-brain barrier. Journal of Materials Science-Materials in Medicine, 2013;24(10):2371-2379. Journal of Materials Science-Materials in Medicine can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands (see also Brain Research).
Our news journalists report that additional information may be obtained by contacting F. Yan, Capital Med Univ, Sch Chem Biol & Pharmaceut Sci, Beijing 100069, People's Republic of China. Additional authors for this research include Y. Wang, S.Z. He, S.T. Ku, W. Gu and L. Ye.
Keywords for this news article include: Asia, Beijing, Transferrin, Fluoresceins, Hydrocarbons, Nanoparticle, Beta-Globulins, Blood Proteins, Brain Research, Nanotechnology, Spiro Compounds, Blood Brain Barrier, Blood-Brain Barrier, Acute-Phase Proteins, Emerging Technologies, Iron-Binding Proteins, People's Republic of China
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