By a News Reporter-Staff News Editor at Gene Therapy Weekly -- New research on Peptide Proteins is the subject of a report. According to news reporting from Nice, France, by NewsRx journalists, research stated, "During the last 2 decades, progress in deciphering the human gene map as well as the discovery of specific defective genes encoding particular proteins in some serious human diseases have resulted in attempts to treat sick patients with gene therapy. There has been considerable focus on human recombinant proteins which were gene-engineered and produced in vitro (insulin, growth hormone, insulin-like growth factor-1, erythropoietin)."
The news correspondents obtained a quote from the research from the University of Nice Sophia-Antipolis, "Unfortunately, these substances and methods also became improper tools for unscrupulous athletes. Biomedical research has focused on the possible direct insertion of gene material into the body, in order to replace some defective genes in vivo and/or to promote long-lasting endogenous synthesis of deficient proteins. Theoretically, diabetes, anaemia, muscular dystrophies, immune deficiency, cardiovascular diseases and numerous other illnesses could benefit from such innovative biomedical research, though much work remains to be done. Considering recent findings linking specific genotypes and physical performance, it is tempting to submit the young athletic population to genetic screening or, alternatively, to artificial gene expression modulation. Much research is already being conducted in order to achieve a safe transfer of genetic material to humans. This is of critical importance since uncontrolled production of the specifically coded protein, with serious secondary adverse effects (polycythaemia, acute cardiovascular problems, cancer, etc.), could occur. Other unpredictable reactions (immunogenicity of vectors or DNA-vector complex, autoimmune anaemia, production of wild genetic material) also remain possible at the individual level. Some new substances (myostatin blockers or anti-myostatin antibodies), although not gene material, might represent a useful and well-tolerated treatment to prevent progression of muscular dystrophies. Similarly, other molecules, in the roles of gene or metabolic activators [5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR), GW1516], might concomitantly improve endurance exercise capacity in ischaemic conditions but also in normal conditions. Undoubtedly, some athletes will attempt to take advantage of these new molecules to increase strength or endurance. Antidoping laboratories are improving detection methods."
According to the news reporters, the research concluded: "These are based both on direct identification of new substances or their metabolites and on indirect evaluation of changes in gene, protein or metabolite patterns (genomics, proteomics or metabolomics)."
For more information on this research see: From Gene Engineering to Gene Modulation and Manipulation: Can We Prevent or Detect Gene Doping in Sports? Sports Medicine, 2013;43(10):965-977. Sports Medicine can be contacted at: Adis Int Ltd, 41 Centorian Dr, Private Bag 65901, Mairangi Bay, Auckland 1311, New Zealand. (Lippincott Williams and Wilkins - www.lww.com; Sports Medicine - journals.lww.com/sportsmedarthro/pages/default.aspx)
Our news journalists report that additional information may be obtained by contacting G. Fischetto, Univ Nice Sophia Antipolis, LAMHESS, EA 6574, F-06189 Nice, France (see also Peptide Proteins).
Keywords for this news article include: Nice, Biotechnology, France, Europe, Genetics, Amino Acids, Gene Therapy, Bioengineering, Peptide Proteins
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