By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A new study on Hematologic Diseases is now available. According to news reporting out of Hackensack, New Jersey, by NewsRx editors, research stated, "Sickle cell disease (SCD) is an autosomal recessive inherited hematological disorder characterized by chronic hemolysis and vaso-occlusion, resulting in multiorgan dysfunction and premature death. The only known curative therapy for patients with severe SCD is myeloablative conditioning and allo-SCT from HLA-matched sibling donors."
Our news journalists obtained a quote from the research from Hackensack University Medical Center, "In this state of the art review, we discuss current and future considerations including patient selection/eligibility, intensity of conditioning regimens, allogeneic graft sources, graft manipulation, mixed donor chimerism, organ function and stability and autologous gene correction stem cell strategies. Recent novel approaches to promote mixed donor chimerism have included the use of matched unrelated adult donors, umbilical cord blood donors, haploidentical familial donors and the utilization of nonmyeloablative, such as reduced intensity and reduced toxicity conditioning regimens. Future strategies will include gene therapy and autologous gene correction stem cell designs."
According to the news editors, the research concluded: "Prospects are bright for novel stem and cellular approaches for patients with severe SCD, and we are currently at the end of the beginning for utilizing cellular therapeutics for the curative treatment of this chronic and debilitating condition."
For more information on this research see: Allogeneic cellular and autologous stem cell therapy for sickle cell disease: 'whom, when and how'. Bone Marrow Transplantation, 2012;47(12):1489-98. Bone Marrow Transplantation can be contacted at: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA. (Nature Publishing Group - www.nature.com/; Bone Marrow Transplantation - www.nature.com/bmt/)
Our news journalists report that additional information may be obtained by contacting J. Freed, Dept. of Pediatrics, Hackensack University Medical Center, Hackensack, NJ, United States. Additional authors for this research include J. Talano, T. Small, A. Ricci and M.S Cairo (see also Hematologic Diseases).
Publisher contact information for the journal Bone Marrow Transplantation is: Nature Publishing Group, 345 Park Avenue South, New York, NY 10010-1707, USA.
Keywords for this news article include: Biotechnology, Hackensack, New Jersey, Gene Therapy, United States, Bioengineering, Sickle Cell Anemia, Stem Cell Research, Hematologic Diseases, North and Central America.
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