By a News Reporter-Staff News Editor at Journal of Technology -- Investigators publish new report on Radiation Research. According to news reporting originating in Augusta, Georgia, by VerticalNews journalists, research stated, "Prior work has established the zebrafish embryo as an in vivo model for studying the biological effects of exposure to low doses of ionizing radiation. One of the known effects of radiation is to elevate the levels of reactive oxygen species (ROS) in tissue."
The news reporters obtained a quote from the research from Georgia Health Sciences University, "However, ROS are also produced as by-products of normal metabolism and, regardless of origin, ROS produce similar chemical damage to DNA. Here we use the zebrafish embryo model to investigate whether the effects of low-dose (0-1.5 Gy) radiation and endogenous ROS are mechanistically distinct. We increased levels of endogenous ROS by exposure to low concentrations of the quinone drug, menadione. Imaging studies in live embryos showed that exposure to 3 ?M or higher concentrations of menadione dramatically increased ROS levels. This treatment was associated with a growth delay and morphologic abnormalities, which were partially or fully reversible. By contrast, exposure to low doses of ionizing radiation had no discernable effects on overall growth or morphology, although, there was an increase in TUNEL-positive apoptotic cells, consistent with the results of prior studies. Further studies showed that the combined effect of radiation and menadione exposure are greater than with either agent alone, and that attenuation of the expression of Ku80, a gene important for repair of radiation-induced DNA damage, had only a slight effect on menadione sensitivity."
According to the news reporters, the research concluded: "Together, results suggest that ionizing radiation and menadione affect the embryo by distinct mechanisms."
For more information on this research see: Effects of low-dose ionizing radiation and menadione, an inducer of oxidative stress, alone and in combination in a vertebrate embryo model. Radiation Research, 2012;178(5):499-503.
Our news correspondents report that additional information may be obtained by contacting C.L. Bladen, Institute of Molecular Medicine and Genetics, Room CA-3006, Georgia Health Sciences University, Augusta, Georgia, United States. Additional authors for this research include D.J. Kozlowski and W.S Dynan.
Keywords for this news article include: Augusta, Georgia, United States, Radiation Research, North and Central America.
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