Researchers from Beijing Institute of Microbiology and Epidemiology Report Details of New Studies and Findings in the Area of Central Nervous System Infections
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Central Nervous System Diseases. According to news originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Human enterovirus type 71 (EV71) is the major pathogen of hand-foot-and-mouth disease (HFMD) and has been associated with severe neurological disease and even death in infants and young children. The pathogenesis of EV71 infection in the human central nervous system remains unclear."
Our news journalists obtained a quote from the research from the Beijing Institute of Microbiology and Epidemiology, "In this study, human whole genome microarray was employed to perform transcriptome profiling in SH-SY5Y human neuroblastoma cells infected with EV71. The results indicated that EV71 infection lead to altered expression of 161 human mRNAs, including 74 up-regulated genes and 87 down-regulated genes. Bioinformatics analysis indicated the possible roles of the differentially regulated mRNAs in selected pathways, including cell cycle/proliferation, apoptosis, and cytokine/chemokine responses. Finally, the microarray results were validated using real-time RT-PCR with high identity."
According to the news editors, the research concluded: "Overall, our results provided fundamental information regarding the host response to EV71 infection in human neuroblastoma cells, and this finding will help explain the pathogenesis of EV71 infection and virus-host interaction."
For more information on this research see: Global transcriptomic analysis of human neuroblastoma cells in response to enterovirus type 71 infection. Plos One, 2013;8(7):e65948. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)
The news correspondents report that additional information may be obtained from L.J. Xu, Dept. of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Taiwan. Additional authors for this research include T. Jiang, F.J. Zhang, J.F. Han, J. Liu, H. Zhao, X.F. Li, R.J. Liu, Y.Q. Deng, X.Y. Wu, S.Y. Zhu, E.D. Qin and C.F Qin (see also Central Nervous System Diseases).
Keywords for this news article include: Asia, Beijing, Genetics, Oncology, Hematology, Neuroblastoma, People's Republic of China, Central Nervous System Diseases, Central Nervous System Infections.
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