Florida Discuss Findings in X-Ray Technology -->
By a News Reporter-Staff News Editor at Cancer Weekly -- Research findings on X-Ray Technology are discussed in a new report. According to news reporting out of Gainesville, Florida, by NewsRx editors, research stated, "To demonstrate diffuse optical tomography (DOT) corrected fluorescence molecular tomography (FMT) for quantitatively imaging tumor-targeted contrast agents in a 4T1 mouse mammary tumor model. In the first set of experiments, we validated our DOT corrected FMT method using subcutaneously injected 4T1 cells pre-labeled with a near-infrared (NIR) Cy 5.5 dye labeled recombinant amino-terminal fragment (ATF) of the receptor binding domain of urokinase plasminogen activator (uPA), which binds to uPA receptor (uPAR) that is highly expressed in breast cancer tissues."
Our news journalists obtained a quote from the research from the University of Florida, "Next, we apply the DOT corrected FMT method to quantitatively evaluate the ability of sensitive tumor imaging after systemic delivery of new uPAR-targeted optical imaging probes in the mice bearing 4T1 mammary tumors. These uPAR-targeted optical imaging probes are ATF peptides labeled with a newly developed NIR-830 dye being conjugated to magnetic iron oxide nanoparticles (IONPs). Our results have shown that DOT corrected FMT can accurately quantify and localize the injected imaging probe labeled 4T1 cells. Following systemic delivery of the targeted imaging nanoprobes into the mice bearing orthotopic mammary tumors, specific accumulation of the imaging probes in the orthotopic mammary tumors was detected in the mice that received uPAR targeted NIR-830-ATF-IONP probes but not in the mice injected with non-targeted NIR-830-mouse serum albumin (MSA)-IONPs. Additionally, DOT corrected FMT also enables the detection of both locally recurrent tumor and lung metastasis in the mammary tumor model 72 hrs after systemic administration of the uPAR-targeted NIR-830-labeled ATF peptide imaging probes."
According to the news editors, the research concluded: "DOT corrected FMT and uPAR-targeted optical imaging probes have great potential for detection of breast cancer, recurrent tumor and metastasis in small animals."
For more information on this research see: DOT corrected fluorescence molecular tomography using targeted contrast agents for small animal tumor imaging. Journal of X-ray Science and Technology, 2013;21(1):43-52. Journal of X-ray Science and Technology can be contacted at: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands (see also X-Ray Technology).
Our news journalists report that additional information may be obtained by contacting Y. Tan, J Crayton Pruitt Family Dept. of Biomedical Engineering, University of Florida, Gainesville, FL 32611-6131, United States. Additional authors for this research include Z. Cao, H.K. Sajja, M. Lipowska, Y.A. Wang, L. Yang and H. Jiang.
Publisher contact information for the Journal of X-ray Science and Technology is: IOS Press, Nieuwe Hemweg 6B, 1013 BG Amsterdam, The Netherlands.
Keywords for this news article include: Florida, Gainesville, United States, X-Ray Technology, North and Central America.
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